Results 131 to 140 of about 214,725 (249)

Evidence for a Cu(II)‐Catalysed CuAAC Reaction: A Combined Experimental and Computational Study

Angewandte Chemie, EarlyView.
A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Matthew J. Andrews, Thomas M. Richardson, Dean D. Roberts, Aitor Maestro, Timothy A. Hilton, Lia Sotorrios, Carlos Martín‐Fernández, Luca Craciunescu, Frederik Peschke, Aidan P. McKay, Stuart A. Macgregor, Glenn A. Burley, Allan J. B. Watson   +12 more
wiley   +2 more sources

A picture is worth a thousand diffraction spots: using photometry and computer vision to perform rapid high-throughput sample-versatile serial crystallography. [PDF]

IUCrJ
Coulson BA, Lewis SG, Orr C, Hatcher LE, Allan DR, Warren M.   +5 more
europepmc   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Additive-driven microwave crystallization of tyramine polymorphs and salts: a quantum crystallography perspective. Corrigendum. [PDF]

IUCrJ
Grabowski S, Nowakowska K, Butkiewicz H, Hoser A, Wesełucha-Birczyńska A, Seidler T, Moskal P, Gryl M.   +7 more
europepmc   +1 more source

[O─I─O]+ Halogen‐Bonded Complexes of Pyridine N‐Oxides

Angewandte Chemie, EarlyView.
The missing puzzle of 3‐center‐4‐electron halogen‐bonded complexes viz. [O─I─O]+ of pyridine N‐oxides are structurally characterized by x‐ray diffraction. Monodentate N‐oxide O‐atom acts as the halogen bond acceptor. Their solution complexations are characterized by 15N NMR spectroscopy.
Rakesh Puttreddy, Sergi Burguera, Antonio Frontera, Kari Rissanen   +3 more
wiley   +2 more sources

Structural physiology of distinctive water channels elucidated by cryo-EM. [PDF]

IUCrJ
Kozai D, Suzuki S, Kamegawa A, Fujiyoshi Y.   +3 more
europepmc   +1 more source

Kinetically Stable Boron‐Heteroatom Bonds

Angewandte Chemie, EarlyView.
This study investigates the kinetic stability of boron‐heteroatom bonds in N‐methyliminodiacetic acid (MIDA) boronates. The hemilabile nature of the ligand enables the synthesis of molecules that would otherwise be considered too hydrolytically labile. Depending on the structure, acid‐promoted migration of the boryl group was found to produce compounds
Alina Trofimova, Ben Zhen Huang, Harjeet S. Soor, Brandon White, Aleksandra Holownia, Yury Lebedev, Alan J. Lough, Travis Dudding, Andrei K. Yudin   +8 more
wiley   +2 more sources

The evolving role of structural biology in pharma: integration of X-ray crystallography, cryo-electron microscopy and beyond. [PDF]

Acta Crystallogr D Struct Biol
Chrencik JE, Su HP, Gomez Llorente Y, Palte RL, Klein DJ, Hayes RP, Antine SP, Asmar-Rovira GA, Bertoletti N, Byrne NJ, Carroll BL, Cordeiro CD, Curfman K, Dutko J, Eddins MJ, Fischmann T, Govindarajan B, Hecksel CW, Ho T, Hollenstein K, Hong MR, Hruza A, Ishchenko A, Jaime-Garza M, Jaremko MJ, Knox HL, Kostas J, Krishnamurthy H, Manolaridis I, Noland CL, Partridge AT, Patel SB, Reichert P, Reid JC, Felisberto-Rodrigues C, Shintre CA, Shipman JM, Tamilselvan E, Walker ME, Walker SN, Wang R, Wright KM, Yen TJ, Yoo BK, Gabelli SB.   +44 more
europepmc   +1 more source

Reactions of Terminal Olefins With Iron Carbenes

Angewandte Chemie, EarlyView.
Iron carbenes react with terminal olefins and show productive metathesis or metathesis‐divergent pathways depending on the nature of the olefin. Reactions proceed through 2π + 2π cycloadditions to generate transient metallacyclobutane intermediates that undergo cycloreversion to generate the metathesis product or the metathesis‐divergent β‐hydride ...
Zachary S. Lincoln, Melissa R. Hoffbauer, Vlad M. Iluc   +2 more
wiley   +2 more sources

Crystallography-inspired hierarchical multiscale mechanical metamaterials. [PDF]

NPJ Metamater
Cai J, Li Y, Seyedkanani A, Lu P, Nohair B, Akbarzadeh A.   +5 more
europepmc   +1 more source