Low Symmetry Cage Complexes Formed by Metalation of Symmetric Hexa‐Cationic Organic Cages
Threefold symmetric hexa‐cationic hydrazone cages coordinate a range of transition metal ions upon deprotonation. When the cage contains ethyl solubilising groups the expected threefold symmetric cage complexes are observed, however when the cage contains alkoxy solubilising groups persistent low symmetry cage complexes form.
Rosemary J. Goodwin+2 more
wiley +2 more sources
Mass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1. [PDF]
Ramanandana P+9 more
europepmc +1 more source
Discrete Actuation of Water‐Responsive Crystalline Metal–Peptide Frameworks
We design metal–peptide frameworks that exhibit either continuous or discrete threshold water‐responsive actuation by tuning water‐binding affinities and structural dynamics. In the continuous actuation mode, water molecules evaporate sequentially due to varying interaction strengths and structural roles.
Hui Yuan+12 more
wiley +2 more sources
Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators
LumiPK, a novel environment‐sensitive fluorescent tracer, enables direct monitoring of allosteric ligand engagement with pyruvate kinase fused with nanoluciferase (Nluc), focusing on the liver isoform (PKL). In NanoBRET, and fluorescence indicator displacement assays, LumiPK shows high affinity and validates known allosteric modulators of PKL.
Oscar Nilsson+9 more
wiley +2 more sources
Multipoint Coordinative Capture of Olefinic Substrates Utilizing Metal-Carbon Bonds by Macrocyclic Complex. [PDF]
Sugawara K, Omoto K, Nakamura T.
europepmc +1 more source
Mechanochemical Synthesis and Electron Crystallography Characterization of van der Waals Lanthanoid 2D Metal-Organic Frameworks. [PDF]
Lorenzo F+9 more
europepmc +1 more source
Rational Design of a Foldon-Derived Heterotrimer Guided by Quantitative Native Mass Spectrometry. [PDF]
Liu X+4 more
europepmc +1 more source