Results 51 to 60 of about 412,410 (289)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Software development for implementing a model of porous structures based on three periodic surfaces
Физика волновых процессов и радиотехнические системы, 2022 Based on the original algorithm for generating three periodic surfaces implemented in the ToposPro information and analytical system, a mathematical model of a porous material was developed.
Mikhail I. Smolkov, Alexander F. Krutov
doaj +1 more source
A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography [PDF]
, 2015 In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL) operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to ...
Madsen, A, Van Thor, JJ
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Crystallography and Geopolitics [PDF]
Science, 2014 Developed and developing nations recognize that innovation is key to their economies. Connecting this with the discipline of crystallography may not seem immediately apparent, but during the past century, understanding the structure of matter has transformed industries and created new frontiers, from the design of new medicines and materials to ...
openaire +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]
, 2013 Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Canning, Peter +3 more
core +3 more sources
Chemical Science, 2017 Quantum crystallography combines quantum chemistry and experimental diffraction or scattering to provide both enhanced wavefunctions and charge densities.
Grabowsky, Simon +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Combinatorial problems of (quasi-)crystallography
, 2002 Several combinatorial problems of (quasi-)crystallography are reviewed with special emphasis on a unified approach, valid for both crystals and quasicrystals. In particular, we consider planar sublattices, similarity sublattices, coincidence sublattices,
Baake, Michael, Grimm, Uwe
core +3 more sources