Results 71 to 80 of about 491,196 (368)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Point groups in crystallography [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2008 Two dual spaces are extensively used in crystallography: the point space E n , hosting the crystal pattern; and the vector space V n , where face normals and reciprocal-lattice vectors are defined. The term "point group" is used in crystallography to indicate four different types of groups in these two spaces.
Nespolo, Massimo, Souvignier, B.
openaire +7 more sources
The Effect of the Position of the Pyridine Nitrogen Atom in the Tridentate NN'O Schiff Base Ligand on the Type of Coordination Polymer of the Copper(II) Complex: A Crystallographic Study [PDF]
شیمی کاربردی روزCoordination polymers (CPs) are synthesized using bridging organic ligands and metal ions, depending on the geometric coordination of the metal, the bridging ligands, and the donor atoms present in these ligands, various one-, two-, or three-dimensional ...
Kimia Forooghi +2 more
doaj +1 more source
The first mononuclear PtIII complex. Molecular structures of (NBu4)[PtIII(C6Cl5)4] and of its parent compound {NBu4}2[PtII(C6Cl5)4]·2CH2Cl2 [PDF]
, 1984 (NBu4)[PtIII(C6Cl5)4], fully characterized by crystallographic, spectral, and magnetic measurements has been isolated by oxidation with halogens or TICl3 of the parent compound (NBu4)2[PtII(C6CL5)4], which has also been analysed by X-ray ...
Bau, Robert +5 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Macromolecular X-ray crystallography (MX) is the most prolific structure determination method in structural biology but is limited by radiation damage.
E. de la Mora +9 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley +1 more source
An integrated web resource for crystallography
Data Science Journal, 2006 A recurring theme during the CODATA 2000 conference (Lake Maggiore, Italy, 15 - 19 October 2000) was the increasing convergence in data-rich branches of science between the storage and retrieval of data and the publication of conclusions drawn from the ...
Brian McMahon
doaj +1 more source
Frontiers in Plant Science, 2021 SUGARWINs are PR-4 proteins associated with sugarcane defense against phytopathogens. Their expression is induced in response to damage by Diatraea saccharalis larvae.
Lorhenn Bryanda Lemes Maia +11 more
doaj +1 more source
A guide to membrane protein X‐ray crystallography
The FEBS Journal, 2020 Membrane proteins play critical physiological roles in all organisms, from ion transport and signal transduction to multidrug resistance. Elucidating their 3D structures is essential for understanding their functions, and this information can also be ...
A. A. Kermani
semanticscholar +1 more source
Structural and functional characterization of chitinase from carnivorous plant Drosera adelae
FEBS Open Bio, EarlyView.A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda +7 more
wiley +1 more source