Results 91 to 100 of about 1,334,872 (294)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Grain Boundary Scars and Spherical Crystallography

, 2003
We describe experimental investigations of the structure of two-dimensional spherical crystals. The crystals, formed by beads self-assembled on water droplets in oil, serve as model systems for exploring very general theories about the minimum energy ...
Bausch, A. R., Bowick, M. J., Cacciuto, A., Dinsmore, A. D., Hsu, M. F., Nelson, D. R., Nikolaides, M. G., Travesset, A., Weitz, D. A.   +8 more
core   +1 more source

Impact of starting alumina powders on densification peculiarities of reactive-sintered YAG:Sm3+ ceramics

Open Ceramics
YAG:Sm3+ (5 at.%) transparent ceramics have been obtained by reactive sintering using different starting Al2O3 powders. Effect of particle size in the 100–400 nm range, morphology and dispersity of starting alumina powders on the properties of YAG:Sm3 ...
O․O․ Matvienko, I․O․ Vorona, S․V․ Parkhomenko, A․E․ Balabanov, А․Т․ Budnikov, A․D․ Tymoshenko, P․V․ Mateychenko, А․V․ Tolmachev, V․N Baumer, G․V․ Grygorova, Ya. Korol, R․P․ Yavetskiy   +11 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The technology of microcircuit assembly on flexible polyimide substrate

Технологія та конструювання в електронній апаратурі, 2010
The research is devoted to technology of microcircuit assembly on flexible polyimide substrate. It is proved that such microcircuits provide high reliability and have advantage over other IC models when applied in hermetic micro-assemblies in ...
Н. И. Плис, В. Г. Вербицкий, В. Д. Жора, В. Н. Волнистов, В. П. Грунянская, H. H. Сергеева   +5 more
doaj  

LABORATORY EQUIPMENT DURING PHARMACEUTICAL DEVELOPMENT OF SEMI-SOLID PREPARATIONS

Разработка и регистрация лекарственных средств, 2019
Introduction. When developing drugs it is necessary to use laboratory equipment that simulates pilot and industrial equipment. For the production of semi-solid preparations the key equipment are rotor-stator dispersers and vacuum reactors-homogenizers ...
N. A. Lyapunov, E. P. Bezuglaya, A. N. Lyapunov, I. A. Zinchenko, K. Yu. Bryleva, A. A. Lysokobilka   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Radiation-resistant plastic scintillators [PDF]

Ядерна фізика та енергетика
Fluorinederivatives of 4'-phenyl-3-hydroxyflavone have been synthesized and used as activators for radiation-resistant plastic scintillators based on polystyrene. Plastic scintillators containing 1.0 wt.
D. A. Yelisieiev, O. V. Yelisieieva, Yu. О. Нurkalenko, P. М. Zhmurin, V. D. Alekseev, R. P. Svoiakov   +5 more
doaj   +1 more source

Real-time dynamic holographic image storage device [PDF]

, 1990
A real-time dynamic holographic image storage device uses four-wave mixing in a pair of photorefractive crystals. An oscillation is produced between the crystals which can be maintained indefinitely after the initial object beam is discontinued.
Lafleur, Sharon S., Montgomery, Raymond C.   +1 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source