Results 91 to 100 of about 745,236 (302)
LABORATORY EQUIPMENT DURING PHARMACEUTICAL DEVELOPMENT OF SEMI-SOLID PREPARATIONS
Разработка и регистрация лекарственных средств, 2019 Introduction. When developing drugs it is necessary to use laboratory equipment that simulates pilot and industrial equipment. For the production of semi-solid preparations the key equipment are rotor-stator dispersers and vacuum reactors-homogenizers ...
N. A. Lyapunov +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Atomistic simulation of biaxial liquid crystals and mixtures of liquid crystals [PDF]
, 2007 In this thesis molecular dynamics (MD) simulations at a fully-atomistic level have been undertaken to study the biaxiality and the structure of the liquid crystalline phase formed by the para-heptylbenxoate diester of 2.5-bis-(p-hydroxyphenyl)-1,3,4 ...
Pelaez Laguno, Jorge
core
Open CeramicsYAG:Sm3+ (5 at.%) transparent ceramics have been obtained by reactive sintering using different starting Al2O3 powders. Effect of particle size in the 100–400 nm range, morphology and dispersity of starting alumina powders on the properties of YAG:Sm3 ...
O․O․ Matvienko +11 more
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Semiconductor Physics, Quantum Electronics & Optoelectronics, 2019 L-arginine-phosphate doped Potassium Dihydrogen Phosphate single crystals with 0.2…4.4 wt.% concentration in the solution was grown on a point seed by the method of temperature reduction.
E.I. Kostenyukova
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
AIP Advances, 2018 Chemical shifts and spin–lattice relaxation times are measured using 1H MAS NMR, 13C CP/MAS NMR, and 14N MAS NMR techniques to understand the structural geometry and dynamics of the alkyl and ammonium groups in layered perovskite (CH3CH2CH2NH3)2CuCl4 ...
Seong Eun Jang, Mi Jung Kim, Ae Ran Lim
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Radiation-resistant plastic scintillators [PDF]
Ядерна фізика та енергетикаFluorinederivatives of 4'-phenyl-3-hydroxyflavone have been synthesized and used as activators for radiation-resistant plastic scintillators based on polystyrene. Plastic scintillators containing 1.0 wt.
D. A. Yelisieiev +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source