Results 71 to 80 of about 745,236 (302)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Particles with Internal Degrees of Freedom
East European Journal of PhysicsA development of a structurally complex particle concept to the case of general interaction potentials between its components is proposed. A structurally complex particle is defined by the restricted problem of N+1 bodies of different masses, which is ...
Kostyantyn M. Kulyk +2 more
doaj +1 more source
Discrete Mathematics & Theoretical Computer Science, 2009 In this paper, we introduce a new model of the crystal $B(\Lambda _0)$ of $\widehat{\mathfrak{sl}_{\ell}}$. We briefly describe some of the properties of this crystal and compare it to the combinatorial model of Misra and Miwa. Dans cet article on propose un nouveau modèle du cristal $B(\Lambda _0)$ de \$\widehat{\mathfrak{sl}_{\ell}}$.
openaire +6 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
ON THE IMPERFECTIONS OF CRYSTALS [PDF]
Proceedings of the National Academy of Sciences, 1929 Imperfections of crystals may be either of mechanical or chemical nature. As will appear in the course of this investigation, the phenomena related to the chemical imperfections can hardly be understood without a preliminary knowledge of the mechanical defects of the crystals considered.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Colloquium : disclination loops, point defects, and all that in nematic liquid crystals [PDF]
, 2012 The homotopy theory of topological defects is a powerful tool for organizing and unifying many ideas across a broad range of physical systems. Recently, experimental progress was made in controlling and measuring colloidal inclusions in liquid ...
Kamien, Randall +5 more
core +1 more source
Laser ablation and photostimulated passivation of the surface of Cd1–хZnхTe crystals
Технологія та конструювання в електронній апаратурі, 2011 A new physical method of Cd1–хZnхTe-detectors passivation is proposed — the treatment of crystal surface by a laser ablation (LA) with subsequent photostimulated passivation (PhSP), during wich a high-resistance oxide layer is formed on it’s surface ...
Yu. A. Zagoruiko +6 more
doaj