Results 101 to 110 of about 205,279 (287)

The sellar barrier on preoperative imaging predicts intraoperative cerebrospinal fluid leak: a prospective multicenter cohort study

, 2020
Background: The type of sellar barrier observed between a pituitary tumor and cerebrospinal fluid (CSF) on preoperative magnetic resonance imaging (MRI) may predict intraoperative CSF leak during endonasal pituitary surgery.
Villalonga J. F., Liu J., Cappabianca P., Prevedello D. M., Froelich S., Cavallo L. M., Hardesty D., Cardenas E., Hirtler L., Martinez-Perez R., Bernat A. -L., Abbritti R. V., Solari D., Kaen A., Saenz A., Fuchssteiner C., Valencia-Ramos C., Gomez-Amador J. L., Carrau R., Cervio A., Campero A., Abbritti, Rosaria Viola, Cervio, Andrés Eduardo, Campero, Álvaro, Liu, James, Carrau, Ricardo, Hardesty, Douglas, Hirtler, Lena, Gómez Amador, Juan Luis, Bernat, Anne-Laure, Solari, Domenico, Kaen, Ariel, Cavallo, Luigi M., Prevedello, Daniel M., Martínez Pérez, Rafael, Cappabianca, P, Valencia Ramos, Cristopher, Cardenas, Eugenio, Saenz, Amparo, Fuchssteiner, Christoph, Villalonga, Juan Francisco, Froelich, Sebastien, Rafael Martinez-Perez, Lena Hirtler, Sebastien Froelich, Juan Luis Gomez-Amador, Cristopher Valencia-Ramos, Luigi M. Cavallo, Andrés Cervio, Douglas Hardesty, Amparo Saenz, James Liu, Ariel Kaen, Christoph Fuchssteiner, Juan F. Villalonga, Domenico Solari, Alvaro Campero, Anne-Laure Bernat, Rosaria Viola Abbritti, Daniel M. Prevedello, Paolo Cappabianca, Ricardo Carrau, Eugenio Cardenas   +62 more
core   +1 more source

Oral Actinomyces Species Exposure is Associated with Anxiety‐Like Behavior, Mitochondrial Remodeling, and Altered GABAergic Pathways

Advanced Science, EarlyView.
Oral exposure to cannabis‐associated Actinomyces species, particularly A. meyeri, is associated with anxiety‐like behavior in mice in the absence of detectable bacterial translocation or overt systemic inflammation. These findings support a potential oral‐brain metabolic axis involving candidate metabolites such as arginine and argininosuccinate ...
Tabinda Salman, Zhenwu Luo, Douglas Johnson, Arshad A. Noorani, Zhuang Wan, Bogdan Bordieanu, Zhi‐wei Ye, Rachel D. Penrod, Hongxu Xian, Sylvia Fitting, Peter W. Kalivas, Wei Jiang   +11 more
wiley   +1 more source

Fluoroscopically-guided epidural blood patch for spontaneous intracranial hypotension

Journal of Anaesthesiology Clinical Pharmacology, 2015
We present three patients with spontaneous intracranial hypotension who failed conservative treatment and were treated with image-guided epidural blood patch close to the cerebrospinal fluid (CSF) leak site.
Manish Shah, David M Giampetro, Paul Kalapos, Julia C Caldwell   +3 more
doaj   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

MRI myelography for diagnosis and targeted blood patching of multilevel thoracic spine CSF leaks: Report of 2 cases

Radiology Case Reports, 2019
In patients with occult cerebrospinal fluid (CSF) leaks or CSF leak syndrome, orthostatic headaches are a common presenting symptom. Although computed tomography (CT) myelography has historically been the gold standard for diagnosis with radioisotope ...
Yi Yang, MD, MPH, Kevin Carr, MD, Yafell Serulle, MD, PhD, Ravishankar Shivashankar, MD   +3 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Comprehensive Techniques in CSF Leak Repair and Skull Base Reconstruction /

, 2013
Written by international leading experts in the field of skull base surgery, this publication provides a comprehensive description of both the etiology and management of defects arising in the anterior skull base.
Bleier, B.S.
core