Results 41 to 50 of about 205,279 (287)

Fat graft in cerebrospinal fluid leak repair after sellar and parasellar lesion surgery of 2000 patients; a multicenter study

Interdisciplinary Neurosurgery, 2022
Introduction: This study investigates the outcome of cerebrospinal fluid leakage repair after endoscopic transsphenoidal surgery (ETSS) sellar and parasellar lesions with fat graft.
Guive Sharifi, Arefeh Bahranian, Esmaeil Mohammadi, Nader Akbari Dilmaghani   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Risk Factors and Clinical Outcomes of Cerebrospinal Fluid Leakage Following Spinal Surgery: Insights from a Single-Center Study

Journal of Spine Practice
Background Cerebrospinal fluid (CSF) leak is a known complication of spine surgery, and an effective protocol for prevention, recognition, and treatment of postoperative CSF leak is essential to avoid a cascade of associated adverse outcomes, such as ...
Abdulhadi Y. Algahtani, Khalid Talal Alghamdi, Hamzah A. Alsharif, Ahood Ahmad A Mahjari, Abdulaziz M. Alghamdi, Nawaf A. Bin Khamis, Reuof I. Althegfi, Alwaleed K. Aloufi, Wed Talal Alghamdi, Hussein Matouq Kheshaifat   +9 more
doaj   +1 more source

A Case of Petrous Apex Meningocele: Unusual Presentation of Cerebrospinal Fluid Leak Following Adenoidectomy [PDF]

Journal of Rhinology, 2020
Cerebrospinal fluid (CSF) leak is possible and can be a cause of recurrent bacterial meningitis. Petrous apex meningocele (PAM) is mostly asymptomatic and is often found during incidental imaging tests.
Byung Kil Kim, Yujin Heo, Doo-Sik Kong, Sang Duk Hong   +3 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Recurrent Spontaneous Bilateral Subdural Hemorrhage as a Consequence of High-Cervical Spontaneous CSF Leak—Lessons for Neurosurgeons

Indian Journal of Neurosurgery, 2021
Spontaneous intracranial hypotension (SIH) is rare. It presents as intractable posture headache and is identified by radiological findings. It is confirmed by cerebrospinal fluid (CSF) manometry and myelography, and treatment is carried out with the help
Venugopal Subramaniam, Sibhi Ganapathy, S. Shivananda, K. N. Nagabhushan, Raghu Murthy   +4 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Correlating the Neuro-ophthalmic Features in IIH with sCSF Leak [PDF]

, 2023
A spontaneous cerebrospinal fluid (CSF) leak occurs when the CSF egresses from the subarachnoid space of teh anterior or middle cranial fossa into the surrounding sinonasal or middle ear cavities through a dehiscence of the lamia ...
Shahlaie, Kiarash, Do, Timothy, Steele, Toby, Strong, E Bradley, Liu, Yin Allison   +4 more
core   +1 more source

Brain Spontaneous Intracranial Hypotension Score for Treatment Monitoring After Surgical Closure of the Underlying Spinal Dural Leak. [PDF]

, 2022
BACKGROUND Spontaneous intracranial hypotension (SIH) is a debilitating condition requiring effective treatment; however, objective data on treatment response are scarce.
Ulrich, Christian, Dobrocky, Tomas, Branca, Mattia, Gralla, Jan, Beck, Jürgen, Pilgram-Pastor, Sara, Kaesmacher, Johannes, Rohner, Roman, Piechowiak, Eike I., Raabe, Andreas, Häni, Levin, Mordasini, Pasquale, Cianfoni, Alessandro, Schär, Ralph T., Mattia Branca, Alessandro Cianfoni, Andreas Raabe, Ulrich, Christian T., Sara Pilgram-Pastor, Pasquale Mordasini, Johannes Kaesmacher, Christian Ulrich, Roman Rohner, Levin Häni, Jan Gralla, Ralph T. Schär, Tomas Dobrocky, Eike I. Piechowiak, Jürgen Beck   +28 more
core   +3 more sources

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source