Results 71 to 80 of about 205,279 (287)
Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang +12 more
wiley +1 more source
Transnasal endoscopic management of anterior cerebrospinal fluid (CSF) leak: experience from a large case series [PDF]
, 2017 Transnasal endoscopic management of anterior cerebrospinal fluid (CSF) leak: experience from a large case ...
Cazzador, D +8 more
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Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
Advanced Science, EarlyView.In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang +14 more
wiley +1 more source
Case Reports in Medicine, 2010 A 41-year-old female patient was admitted with streptococcal meningitis on a background of 5-month history of CSF rhinorrhoea. Imaging revealed an extensive skull base lesion involving the sphenoid and ethmoid sinuses, the pituitary fossa with ...
Neil Barua +4 more
doaj +1 more source
Spontaneous Cerebrospinal Fluid (CSF) Leak and Idiopathic Intracranial Hypertension (IIH)
, 2013 IIH is increasingly recognized as a cause of spontaneous CSF-leak in the ENT literature. The diagnosis of IIH is classically made a few weeks after surgical repair of the CSF-leak, because of occurrence of IIH ...
Mario Perez Rueda; Omer Y. Bialer; Nancy J. Newman; Beau B. Bruce; Valﾎrie Biousse
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Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
Case Reports in Infectious Diseases, 2019 Immune deficiency is usually the underlying predisposing factor for cryptococcal meningitis, though there have been case reports of immunocompetent patients presenting with same.
Chukwunonso Chime +6 more
doaj +1 more source
Evaluation of prostaglandin D2 as a CSF leak marker: implications in safe epidural anesthesia
, 2011 Sirish Kondabolu, Rishimani Adsumelli, Joy Schabel, Peter Glass, Srinivas PentyalaDepartment of Anesthesiology, School of Medicine, Stony Brook Medical Center, Stony Brook, New York, USABackground: It is accepted that there is a severe risk of dural ...
Adsumelli R +4 more
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