Results 81 to 90 of about 3,801 (175)

Computational investigation in inhibitory effects of amantadine on classical swine fever virus p7 ion channel activity

Scientific Reports
Classical swine fever virus (CSFV) p7 viroporin plays crucial roles in cellular ion balance and permeabilization. The antiviral drug amantadine effectively inhibits viral replication by blocking the activity of CSFV p7 viroporin.
Xiaowei Chen, Xiao Wang
doaj   +1 more source

In vitro inhibition of CSFV replication by retroviral vector-mediated RNA interference

Journal of Virological Methods, 2010
Classical swine fever (CSF) is a highly contagious viral disease of pigs which causes major economic losses worldwide. No specific drug is currently available for the effective treatment of CSFV infection. RNA interference (RNAi) technology depends on effective delivery systems, for which several effective vectors have recently been developed.
Li, Jiangnan, Guo, Huancheng, Shi, Zixue, Tu, Changchun   +3 more
openaire   +2 more sources

Transcriptome analysis of 3D4/21 cells expressing CSFV NS4B

Frontiers in Microbiology
Classical swine fever (CSF) caused by classical swine fever virus (CSFV) has resulted in severe losses to the pig industry worldwide. CSFV non-structural protein 4B (NS4B) plays a crucial role in CSFV replication and pathogenicity. However, the function of NS4B is still limited during CSFV infection.
Wang Dong, Huifang Lv, Yuzhen Song, Yujin Lv, Xiapeng Xu, Huiyuan Jing, Zhifeng Peng, Xinghui Song, Yongbin Guo   +8 more
openaire   +3 more sources

Antiviral Role of IFITM Proteins in Classical Swine Fever Virus Infection

Viruses, 2019
The proteins IFITM1, IFITM2, and IFITM3 are host effectors against a broad range of RNA viruses whose roles in classical swine fever virus (CSFV) infection had not yet been reported.
Cheng Li, Hongqing Zheng, Yifan Wang, Wang Dong, Yaru Liu, Liang Zhang, Yanming Zhang   +6 more
doaj   +1 more source

Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells

Virulence, 2020
Classical swine fever virus (CSFV), a positive-sense RNA virus, hijacks cell host proteins for its own replication. Rab18, a small Rab GTPase, regulates intracellular membrane-trafficking events between various compartments in cells and is involved in ...
Liang Zhang, Di Zhao, Mingxing Jin, Mengzhao Song, Shanchuan Liu, Kangkang Guo, Yanming Zhang   +6 more
doaj   +1 more source

mTORC1 Negatively Regulates the Replication of Classical Swine Fever Virus Through Autophagy and IRES-Dependent Translation

iScience, 2018
Summary: Classical swine fever virus (CSFV) can utilize diverse host signaling pathways for its replication; however, the cross talk between mammalian target of rapamycin (mTOR) and CSFV remains unknown.
Qinghua Luo, Li Zhang, Feng Wei, Qiang Fang, Fei Bao, Shijiang Mi, Nan Li, Chengming Wang, Yan Liu, Changchun Tu   +9 more
doaj   +1 more source

Rapid Differential Detection of Wild-Type Classical Swine Fever Virus and Hog Cholera Lapinized Virus Vaccines by TaqMan MGB-Based Dual One-Step Real-Time RT-PCR

Veterinary Sciences
To establish a rapid real-time RT-PCR method for differentiating wild-type classical swine fever virus (CSFV) strains from vaccine strains (HCLV), we designed a universal primer targeting the NS3 gene to detect wild-type CSFV strains and vaccine strains ...
Yongzhe Zhang, Meiqi Wang, Yajuan Sun, Xingyu Xiao, Songsong Wang, Peng Li, Yansong Liu, Hongri Zhao, Yan Meng, Rui Yin   +9 more
doaj   +1 more source

sIFITM1, sIFITM3, and sViperin antiviral proteins as inactivated CSFV vaccine adjuvants. [PDF]

Front Vet Sci
Vaccine adjuvants are now widely utilized in vaccine formulations. The IFN-Stimulated Genes (ISGs) family, play crucial roles in immune regulation and exhibit broad-spectrum antiviral activity. However, limited studies have investigated the potential of ISGs as vaccine adjuvants.
Liu S, Zhou W, Ye H, Qiu F, Gu R, Xu E, Chen JL.   +6 more
europepmc   +4 more sources

The reduction of CSFV transmission to untreated pigs by the pestivirus inhibitor BPIP: A proof of concept

Veterinary Microbiology, 2009
5-[(4-Bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP) is a representative molecule of a novel class of highly active in vitro inhibitors of the replication of Classical swine fever virus (CSFV). We recently demonstrated in a proof of concept study that the molecule has a marked effect on viral replication in CSFV-infected pigs.
R, Vrancken, A, Haegeman, J, Dewulf, J, Paeshuyse, G, Puerstinger, M, Tignon, M-F, Le Potier, J, Neyts, F, Koenen   +8 more
openaire   +3 more sources

Effects of Astragalus Polysaccharide on Immune Responses of Porcine PBMC Stimulated with PRRSV or CSFV

PLoS ONE, 2012
Astragalus polysaccharide (APS) has been used as an immunomodulator that can enhance immune responses, whereas the immunomodulatory effects of APS on porcine peripheral blood mononuclear cells (PBMCs) exposed to porcine reproductive and respiratory syndrome virus (PRRSV) and classical swine fever virus (CSFV) have not been investigated.Porcine PBMCs ...
Zhuge, Zeng Yu, Zhu, Yao Hong, Liu, Pan Qi, Yan, Xiao Dong, Yue, Yuan; id_orcid 0000-0001-8064-556X, Weng, Xiao Gang, Zhang, Rong, Wang, Jiu Feng   +7 more
openaire   +5 more sources