Results 71 to 80 of about 8,557 (171)
Diagnostic and prognostic value of fecal, serum and endoscopic markers in inflammatory bowel disease and colorectal cancer [PDF]
, 2018 Background. The most important goals of the recent therapies of inflammatory bowel disease (IBD) are to induce and maintain clinical remission and mucosal healing (MH), which can be achieved with anti-TNF-α biological therapy.
Rutka Mariann
core
Scientific rationale behind the development and approval of biosimilar infliximab (CT-P13) in Europe [PDF]
Expert Review of Clinical Immunology, 2015 Biosimilars are drugs developed to be highly similar to their originator biologic (or ‘reference medicinal product’) with no clinically meaningful differences in purity, efficacy or safety. Production of biologics and biosimilars is highly complex and sensitive, with any change in manufacturing process having a potential impact on efficacy and safety ...
Ulf, Müller-Ladner +3 more
openaire +2 more sources
Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy
Acta Ophthalmologica, EarlyView.Abstract Purpose To determine the histological differences between Fuchs endothelial corneal dystrophy (FECD) cases with and without the most common genetic risk factor, expansion of a CTG repeat (CTG18.1) within the TCF4 gene. Methods Formalin‐fixed paraffin‐embedded corneal tissues were compared retrospectively, and CTG18.1 status was determined from
Anne‐Marie S. Kladny +5 more
wiley +1 more source
Cell Proliferation, EarlyView.In the oxygen‐induced retinopathy (OIR) mouse model, two distinct microglial subpopulations play opposing roles: highly glycolytic microglia (HGM) promote neovascular formation via Pkm2, while Mrc1/CD206‐positive phagocytosis‐associated microglia (PAM) facilitate its regression.
Yuan Ma +20 more
wiley +1 more source
INTRAABDOMINAL DESMOPLASTIC SMALL ROUND CELL TUMOR: CASE REPORT WITH LITERATURE REVIEW [PDF]
Euromediterranean Biomedical Journal, 2015 Intra-abdominal desmoplastic small round cell tumors are rare aggressive neoplasms, with a very poor prognosis, observed in young adults with a male predominance.
Joseph Kreiker
doaj +1 more source
Junior doctors' experiences with vulnerability: A rich picture study
Medical Education, EarlyView.Abstract Context The transition to practice is a context in which junior doctors can feel vulnerable. Although we know junior doctors experience intense emotions during their transition to practice, we still do not understand the role of vulnerability in this process. Vulnerability may cause emotional suffering but also offers an opportunity for growth
Titia S. van Duin +4 more
wiley +1 more source
A Review on Biosimilar Infliximab, CT-P13, in the Treatment of Inflammatory Bowel Disease [PDF]
Immunotherapy, 2017 The introduction of biological agents has led to significant changes in the treatment of inflammatory bowel disease (IBD). The relatively high price of infliximab (IFX) and the expiration of the patents led to the introduction of biosimilar agents. CT-P13 was the first IFX biosimilar approved in the same indications as the reference product; however ...
Farkas Klaudia, Molnár Tamás
openaire +3 more sources
Musculoskeletal Care, Volume 24, Issue 2, June 2026.ABSTRACT Background Patients with non‐serious low back pain (LBP) may present to hospital emergency departments expecting high‐value care when community healthcare options are perceived as inaccessible or ineffective. Objectives This study explored the experiences and expectations of patients following a LBP‐related admission to provide insight into ...
Joseph F. Orlando +4 more
wiley +1 more source
eJHaem, Volume 7, Issue 2, April 2026.Abstract Background Chronic myeloid leukemia (CML) presenting in blast crisis (BC) is uncommon in the era of tyrosine kinase inhibitor (TKI) treatment, and T‐lymphoblastic BC is exceptionally rare. We report a case of T‐lymphoid BC presenting with extreme hyperleukocytosis.
E. Somasundaram +4 more
wiley +1 more source