Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Deciphering Core Geometry for the Rational Design of Copper(I) Iodide Cluster Scintillators Toward Computed Tomography Imaging. [PDF]
Angew Chem Int Ed EnglZhang P +6 more
europepmc +1 more source
Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy
Advanced Science, EarlyView.This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang +5 more
wiley +1 more source
To Explore or Not? Conservatively Managed Brachial Artery Injury with Good Collateral Flow After Elbow Reduction: A Case Report. [PDF]
J Orthop Case RepPaes L, Faisal M, Maini L.
europepmc +1 more source
Selective Polarity Control of Metal Oxide Semiconductors for Complementary Logic Gates
Advanced Science, EarlyView.A scalable electrochemical doping strategy enables in situ p‐to‐n polarity conversion in tin oxide (SnO) thin films using electrolyte gating. Both the pristine p‐type SnO transistor and the electrochemically converted n‐type SnO2 transistor exhibited noticeable and stable electrical performance.
Dong Hyun Park +6 more
wiley +1 more source
Nominal material density may not reflect TPS-relevant density for 3D-printed surgical reconstruction implants: An educational case study. [PDF]
J Appl Clin Med PhysEhler ED, Edlund S, Reynolds M.
europepmc +1 more source
Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes
Advanced Science, EarlyView.Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen +8 more
wiley +1 more source
Coinfection of Pneumocystis jirovecii and Aspergillus fumigatus in the lung: A case report. [PDF]
Medicine (Baltimore)He MH, Chen XL, Feng BT.
europepmc +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Predicting Traumatic Brain Injury Outcomes: The Intersection of Clinical Signs, Laboratory Indicators and Radiology. [PDF]
Korean J NeurotraumaSehar Z, Dar JR, Hela AH.
europepmc +1 more source