Results 191 to 200 of about 114,627 (294)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity

Angewandte Chemie, EarlyView.
A native ene‐reductase, XenA, was repurposed to catalyze the reverse‐enantioselective desaturation of cyclohexanones. The final variant was obtained through extensive protein engineering, combining PROSS‐guided computational design with mutagenesis and screening.
Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu   +4 more
wiley   +2 more sources

Severe Orthopnoea With Positional Paradoxical Breathing: A Response to Continuous Positive Airway Pressure. [PDF]

Cureus
Jakobi JV, Paciorkowski M, Graf K, Brutsche MH.   +3 more
europepmc   +1 more source

Thermostable Bioluminescent Intercalating Dyes for Real‐Time, Integrated Nucleic Acid Amplification and Detection

Angewandte Chemie, EarlyView.
We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter, Harmen J. van der Veer, Sterre de Lignie, Robbert J. de Haas, Renko de Vries, Joost P. H. Schoeber, Anne J. M. Loonen, Adriaan J. C. van den Brule, Maarten Merkx   +8 more
wiley   +2 more sources

Unexplained Positional Hypoxemia in an Elderly Patient: A Case of Platypnea-Orthodeoxia Syndrome. [PDF]

Cureus
Villalobos De Ycaza MA, López Saborio GM, Mora Murillo JJ, Alvarado Sanabria E, Quirós Alvarado M, Leandro Sandí K.   +5 more
europepmc   +1 more source

Comment on “Can Charge Transfer Across C─H···O Hydrogen Bonds Stabilize Oil Droplets in Water?”

Angewandte Chemie, EarlyView.
Nanoscale oil droplets in water are kinetically stable and charged, with a pH dependent electrophoretic mobility. Although the source of this charge is agreed to arise from water, 2 main hypotheses remain: OH− adsorption or electronic charge density displaced via hydrogen bonds. Molecular surface specific experiments are reviewed, that all point to the
P. Singh, C. E. Rani, S. Pullanchery, S. Roke   +3 more
wiley   +2 more sources

Crossing the blood-brain barrier: neurotrauma in disasters and resource-limited settings. [PDF]

Trauma Surg Acute Care Open
Anstadt MJ, Egodage T, Martin MJ, Patel PP.   +3 more
europepmc   +1 more source

Design Guidelines for Anode Modifications to Eliminate Soft Short Circuits in Anode‐Free Na Batteries Under High Current Density With Large‐Capacity Plating, Demonstrated via Initiated Chemical Vapor Deposition (iCVD)

Angewandte Chemie, EarlyView.
This work establishes a laterally homogeneous organic–inorganic hybrid interphase for soft‐short‐free anode‐free sodium metal batteries under extended cycling at high current density and high plating capacity. In contrast to conventional strategies that evolve into laterally heterogeneous interphases and induce localized Na filament growth, the pDFHA ...
Yeongjun Oh, Yuxuan Zhang, Jinwook Baek, Minyoung Kim, Jeongmin Park, Myung Gyu Lee, Chung Soo Kim, Sunghwan Lee   +7 more
wiley   +2 more sources

Unraveling the Enigma of COVID-19 pneumonia and lung diameters: An HR-CT based study. [PDF]

Pak J Med Sci
Mushtaq M, Usmani A, Surti A, Kazmi SHS.
europepmc   +1 more source

Management of malignant central airway stenosis with X-ray-guided Y-shaped covered self-expanding metallic stents: evaluating efficacy and safety. [PDF]

J Thorac Dis
Zheng G, Han A, Feng X, Zhang L, He G.
europepmc   +1 more source