Results 221 to 230 of about 135,797 (305)

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Do aphid endosymbiotic bacteria influence parasitoid searching behaviour through changes in aphid honeydew production?

Ecological Entomology, EarlyView.
Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda, Alexandre Foito, Katharine F. Preedy, Colin J. Alexander, Ankush Prashar, Alison J. Karley   +5 more
wiley   +1 more source

Combining Napsin A expression with circulating tumor cell counts for enhanced identification of pulmonary adenocarcinoma in ground-glass nodules. [PDF]

Transl Cancer Res
Ruan S, Yu H, Song Z, Zhu X, Yuan G, Xie H, Zhang C, Wei T.   +7 more
europepmc   +1 more source

Microbiome‐mediated immunity: Limited support from the gazelle dung beetle

Ecological Entomology, EarlyView.
Digitonthophagus gazella rely on a maternally inherited microbiome passed across generations via a maternal faecal pellet called the pedestal. We experimentally manipulated the presence of the pedestal, providing it to some individuals while withholding it from others to determine how pedestal microbiota may affect beetle immune potential.
Joshua A. Jones, Irene L. G. Newton, Armin P. Moczek   +2 more
wiley   +1 more source

Circulating tumor cells as biomarkers in melanoma: techniques, challenges, and clinical applications. [PDF]

Front Cell Dev Biol
Broseghini E, Durante G, Soru A, Bianchi F, Comito F, Dika E, Ferracin M, Gallerani G.   +7 more
europepmc   +1 more source

Global Banks and Local Rules: The Effects of Macroprudential Policy on US Bank Branch Lending

European Financial Management, EarlyView.
ABSTRACT The discretionary nature of macroprudential policy implementation may stimulate regulatory arbitrage opportunities by global banks, undermining national regulators’ efforts to fine‐tune business, credit or financial cycles within the domestic perimeter. This paper examines how local macroprudential tools affect the lending behaviour of foreign
Carmela D'Avino, Suwan Long, Mimoza Shabani, Maria Tselika   +3 more
wiley   +1 more source

Poverty Over the Life Course: Evidence From Birth to Emerging Adulthood

Family Relations, EarlyView.
ABSTRACT Objective To assess if childhood poverty predicts poverty in emerging adulthood and identify the mechanisms. Background Early‐life poverty elevates the risk of adult economic disadvantage, but the specific pathways require clearer delineation.
Chien‐Chung Huang, Hui‐Fen Lin
wiley   +1 more source