Results 51 to 60 of about 135,797 (305)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CTC quantification.

, 2016
CTC quantification.
André Goergens (2621122), Thomas C. Gauler (511631), Andreas-Claudius Hoffmann (413923), Bernd Giebel (255529), Martin Schuler (162011), Kira Bublitz (2621119), Ivonne Nel (670499), Lazaros Lazaridis (2621116)   +7 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Nanoporous Supramolecular Metal–Organic Framework Based on a Nucleotide: Interplay of the π···π Interactions Directing Assembly and Geometric Matching of Aromatic Tails

Molecules, 2021
Self-assembly is the most powerful force for creating ordered supramolecular architectures from simple components under mild conditions. π···π stacking interactions have been widely explored in modern supramolecular chemistry as an attractive reversible ...
Rosaria Bruno, Teresa F. Mastropietro, Giovanni De Munno, Donatella Armentano   +3 more
doaj   +1 more source

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells [PDF]

Exploration (Beijing)
Engineered micro/nanomaterials enable high‐efficiency CTC capture, release, and multimodal molecular profiling. Integrated with AI‐driven analytics, these platforms decode tumor heterogeneity and metastatic dynamics, advancing real‐time monitoring and precision oncology through DNA, RNA, and protein cross‐scale data fusion.
Li H, Sun J, Liu K, Wang S, Fu B, Zhu H, Cao P, Han X.   +7 more
europepmc   +2 more sources

Aneuploid CTC and CEC

Diagnostics, 2018
Conventional circulating tumor cell (CTC) detection technologies are restricted to large tumor cells (> white blood cells (WBCs)), or those unique carcinoma cells with double positive expression of surface epithelial cell adhesion molecule (EpCAM) for isolation, and intracellular structural protein cytokeratins (CKs) for identification. With respect
openaire   +2 more sources

CTC Quantification.

, 2014
CTC Quantification.
Götz Lehnerdt (670504), Anke Schlueter (670502), Andreas-Claudius Hoffmann (413923), Patrick Weller (670498), Paulette Dountsop (670503), Ivonne Nel (670499), Thomas Gauler (670501), Philipp Hassenkamp (670500), Stephan Lang (164228)   +8 more
core   +1 more source

sj-pdb-5-ctc-10.1177_25152564231211976 - Supplemental material for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae

, 2023
Supplemental material, sj-pdb-5-ctc-10.1177_25152564231211976 for Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae by Sébastien Leterme, Olivier Bastien, Riccardo Aiese ...
Olivier Bastien (7815), Riccardo Aiese Cigliano (4511068), Sébastien Leterme (17463020), Morgane Michaud (17463023), Alberto Amato (3950006)   +4 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CR-CTC: Consistency regularization on CTC for improved speech recognition

CoRR
Published as a conference paper at ICLR ...
Zengwei Yao, Wei Kang 0006, Xiaoyu Yang 0005, Fangjun Kuang, Liyong Guo, Han Zhu 0004, Zengrui Jin, Zhaoqing Li, Long Lin, Daniel Povey   +9 more
openaire   +3 more sources