Results 231 to 240 of about 24,447,859 (342)

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Efficacy and safety of immunosuppressive therapy in connective tissue disease-related immune thrombocytopenia: a systematic review and meta-analysis. [PDF]

Ther Adv Hematol
Zhang Y, Yan X, Grimshaw AA, Wang Y, Li M, Zeng X, Hsieh E, Jiang N.   +7 more
europepmc   +1 more source

Ligand‐driven modulation of chaperone–cochaperone networks shapes proteostasis outcomes

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Protein homeostasis depends on a delicate interplay between folding and degradation, orchestrated by molecular chaperones. Among them, Hsp90 is a central hub, regulating nearly 10% of the proteome through ATP‐driven conformational cycles and selective interactions with cochaperones.
Andrea Magni, Giorgio Bonollo, Gauthier Trèves, Francesco Frigerio, Fabrizio Cinquini, Silvia Pavoni, A. Sofia F. Oliveira, Adrian J. Mulholland, Stefano A. Serapian, Giorgio Colombo   +9 more
wiley   +1 more source

Association of Pericardial Tamponade With Initiation of Sotatercept in a Patient With Eisenmenger Syndrome. [PDF]

Pulm Circ
Aldawsari KA, Simpkin CT, Frank BS, Ivy DD.   +3 more
europepmc   +1 more source

Novel insights into the assembly of the yeast translation initiation multifactor complex: The critical role of eIF5

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The eukaryotic translation initiation is a biological process in which at least a dozen eukaryotic initiation factors (eIFs) are involved. Specifically, eIF3, eIF1, eIF5, and eIF2 as a ternary complex (eIF2‐TC) bound to GTP and methionyl initiator tRNA (Met‐tRNAiMet).
Borja Sáez de la Fuente, Laura Villamayor‐Belinchón, José Rafael Ciges‐Tomas, Marisa López‐Redondo, Carolina Espinosa, Elisabetta Boeri Erba, José L. Llácer   +6 more
wiley   +1 more source

Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity. [PDF]

J Biol Chem
Madsen M, Rønne ME, Petersen AB, Tandrup T, Pilgaard B, Holck J, Aachmann FL, Wilkens C, Klau LJ, Svensson B.   +9 more
europepmc   +1 more source

Elucidation of Molecular Mechanisms of Lipid-Altered Cytotoxicity of TDP-43 Fibrils. [PDF]

ACS Chem Neurosci
Purvinsh Y, Matveyenka M, Kurouski D.
europepmc   +1 more source

CoralFISH_CoNISMa-2010-MAGIC_Cruise_Report [PDF]

, 2010

core  

Prognostic Value of a Cardiopulmonary Exercise Testing‐Derived Summed Score in Idiopathic Pulmonary Fibrosis and Connective Tissue Disease‐Associated Interstitial Lung Disease: A Prospective Cohort Study

Respirology, Volume 31, Issue 5, Page 498-508, May 2026.
A cardiopulmonary exercise testing‐derived summed score effectively predicted mortality or lung transplantation risk in newly diagnosed interstitial lung disease. Higher summed scores (2–5) were associated with markedly lower event‐free survival rates.
Yu‐Lin Tsai, Kai‐Ming Chang, Chung‐Shih Chin, Chiann‐Yi Hsu, Yi‐Hsuan Yu, Yuan‐Yang Cheng, Pin‐Kuei Fu   +6 more
wiley   +1 more source

Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepatocellular carcinoma via targeting the PRMT1-SREBF1 axis-mediated lipid metabolism. [PDF]

J Transl Med
Wang Y, Yuan H, Yu Y, Gou X, Wang Z, Zhou Z, Wang Z, Yan W, Wang H, Yan J.   +9 more
europepmc   +1 more source