Results 11 to 20 of about 10,335 (173)

Notch signaling enhances PASMC proliferation and vascular remodeling in CTEPH

Open Life Sciences
The Notch signaling pathway is implicated in pulmonary vascular remodeling (PVR) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH). This study investigated the role of Notch signaling in PVR using a rat model of CTEPH and performed measurements ...
Aimaier Salamaiti, Mahemuti Ailiman, Abuduhalike Refukaiti, Lu Wen-kui, Guo Yu-jun, Zhao Li   +5 more
doaj   +2 more sources

Minimally Invasive Porcine Model for Chronic Thromboembolic Pulmonary Hypertension. [PDF]

Pulm Circ
ABSTRACT To elucidate the complex pathophysiology of chronic thromboembolic pulmonary hypertension (CTEPH), a disease associated with bilateral fibrotic obstructions of the pulmonary arteries (PA) and microvascular changes, research relies on animal models, which often depend on invasive techniques, including open surgery.
Battilana B, Stoeck CT, Robert F, Senbaklavaci Ö, Weisskopf M, Opitz I.   +5 more
europepmc   +2 more sources

The Therapeutic Efficacy of Drugs Targeting the NO-sGC-cGMP Pathway in Treatment of Patients With Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review. [PDF]

Pulm Circ
ABSTRACT Chronic thromboembolic pulmonary hypertension (CTEPH) is a distinct and potentially curable form of pulmonary hypertension; however, a substantial proportion of patients remain inoperable or experience persistent or recurrent disease. Pharmacological therapies targeting the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate (
Alqarni AA, Aljedani RH, Aldhahir AM, Alasimi AH, AlGarni AA, Alqahtani JS, Alghamdi SM, Siraj RA, Mengash A, Alwafi H.   +9 more
europepmc   +2 more sources

Recognition, diagnosis, and operability assessment of chronic thromboembolic pulmonary hypertension (CTEPH): A global cross‐sectional scientific survey (CLARITY)

Pulmonary Circulation
Early recognition and diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is crucial for improving prognosis and reducing the disease burden.
Grzegorz Kopeć, Paul Forfia, Kohtaro Abe, Amélie Beaudet, Virginie Gressin, Mitja Jevnikar, Catherina Meijer, Yan Zhi Tan, Olga Moiseeva, Karen Sheares, Nika Skoro‐Sajer, Mario Terra‐Filho, Helen Whitford, Zhenguo Zhai, Gustavo A. Heresi   +14 more
doaj   +2 more sources

Balloon pulmonary angioplasty in patients with CTEPH

, 2022
The only curative treatment currently available for chronic thromboembolic pulmonary hypertension (CTEPH) is surgical pulmonary endoarterectomy (PEA). However, several patients may have high risk factors for surgery, or a peripheral disease not amenable ...
Galie N., Matsubara H., Saia F.
core   +1 more source

Frequency and functional characterization of patients with CTEPH and CTED in pulmonary embolism follow-up

, 2022
Die chronisch thromboembolische Erkrankung (CTED) ist ein Erkrankungsbild, welches erst in den letzten Jahren neu definiert wurde und bisher unzureichend charakterisiert ist.
Schmitt, Delia
core   +1 more source

Pulmonary artery angiosarcoma mimicking chronic thromboembolic pulmonary hypertension

Turkish Journal of Vascular Surgery, 2022
Pulmonary artery angiosarcoma (PAA) is an extremely rare malignancy that arises from endothelial cells. The pulmonary trunk is the most common anatomic site of these tumors. However, so far, there have only been a few examples of PAA reported.
Gokhan Kahraman, Omer Koray Hekimoglu, Ipek Kivilcim Oguzulgen, Ebru Sebnem Ayva, Bahadir Gultekin, Hakki Tankut Akay   +5 more
doaj  

Sensitivity of a Simple Noninvasive Screening Algorithm for Chronic Thromboembolic Pulmonary Hypertension after Acute Pulmonary Embolism

TH Open, 2018
Background Recently, we constructed a noninvasive screening algorithm aiming at earlier chronic thromboembolic pulmonary hypertension (CTEPH) detection after acute pulmonary embolism (PE), consisting of a prediction score and combined electrocardiography
Yvonne M. Ende-Verhaar, Dieuwertje Ruigrok, Harm Jan Bogaard, Menno V. Huisman, Lilian J. Meijboom, Anton Vonk Noordegraaf, Frederikus A. Klok   +6 more
doaj   +1 more source

Circulating biomarkers in chronic thromboembolic pulmonary hypertension

Pulmonary Circulation, 2019
Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition characterized with chronic organized thrombi that obstruct the pulmonary vessels, leading to pulmonary hypertension (PH) and ultimately right heart failure.
Meng Zhang, Yunxia Zhang, Wenyi Pang, Zhenguo Zhai, Chen Wang   +4 more
doaj   +1 more source

Organization of pharmacological support of patients with rare diseases in moscow as exemplified by pulmonary arterial hypertension

Медицинский совет, 2018
Orphan diseases are life-threatening, chronic, progressive and leading to a reduction in life expectancy or disability conditions. Patients with rare diseases are one of the vulnerable population groups, which is caused by several factors, such as ...
M. V. Zhuravleva, A. Yu. Lebedeva
doaj   +1 more source