Results 51 to 60 of about 76,124 (233)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

open access: yesAdvanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green   +15 more
wiley   +1 more source

High sensitivity double beta decay study of 116-Cd and 100-Mo with the BOREXINO Counting Test Facility (CAMEO project)

open access: yes, 2000
The unique features (super-low background and large sensitive volume) of the CTF and BOREXINO set ups are used in the CAMEO project for a high sensitivity study of 100-Mo and 116-Cd neutrinoless double beta decay. Pilot measurements with 116-Cd and Monte
Bellini, G.   +14 more
core   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

open access: yesAdvanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo   +8 more
wiley   +1 more source

Three dimensional Lifshitz black hole and the Korteweg-de Vries equation

open access: yes, 2011
We consider a solution of three dimensional New Massive Gravity with a negative cosmological constant and use the AdS/CTF correspondence to inquire about the equivalent two dimensional model at the boundary.
Abdalla, E.   +3 more
core   +1 more source

Adaptive query-based sampling of distributed collections [PDF]

open access: yes, 2006
As part of a Distributed Information Retrieval system a de-scription of each remote information resource, archive or repository is usually stored centrally in order to facilitate resource selection.
C. Zhai   +10 more
core   +4 more sources

Deciphering Intricacies in Directional CO2 Conversion From Electrolysis to CO2 Batteries

open access: yesAdvanced Energy Materials, EarlyView.
This review will delve into the inherent connections and distinctions of CO2‐directed conversion in ECO2RR and CO2 batteries, in terms of product types, catalyst selection, catalytic mechanisms, and electrochemical performances, while proposing a benchmarking framework for the evaluation of CO2 batteries and innovative CO2 battery configurations for ...
Changfan Xu   +5 more
wiley   +1 more source

Do human sinoatrial node cells have t-tubules?

open access: yesTranslational Research in Anatomy, 2021
Every heartbeat is generated by spontaneously depolarizing specialised nodal cells that make up the sinoatrial node (SN). The SN's unique properties depend on two complex mechanisms - the membrane-voltage and the Ca2+ clocks, regulated by strictly ...
Maria A. Petkova, Halina Dobrzynski
doaj   +1 more source

Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]

open access: yes, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D.   +8 more
core   +1 more source

Activation‐Integrated and Memory‐Assisted Dynamic‐Latch Quantizer for Variation‐Tolerant and Low‐Energy Neuromorphic Computing

open access: yesAdvanced Intelligent Systems, EarlyView.
A memory‐assisted dynamic‐latch ADC integrating charge‐trap flash enables ultra‐low‐energy quantization and in‐ADC nonlinear activation for variation‐tolerant neuromorphic computing. Analog‐to‐digital converters (ADCs) remain the dominant area/energy bottleneck in neuromorphic computing (NC) systems.
Jonghyun Ko   +4 more
wiley   +1 more source

The 9th International RASopathies Symposium

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel   +41 more
wiley   +1 more source

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