Results 271 to 280 of about 119,169 (307)
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Two CTLA-4 ligands, separate pHates
Nature Immunology, 2022Preston A. Humphries, Wan-Lin Lo
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IFNγ Mutations Prompt CTLA-4 Inhibitor Resistance
Cancer Discovery, 2017Abstract A recent study pinpoints loss of IFNγ signaling as one reason why many patients do not respond to the CTLA-4 inhibitor ipilimumab. Analyzing whole-exome tumor sequencing data from 16 patients with melanoma, the researchers found multiple copy-number alterations that led to the loss of key IFNγ pathway genes in 12 ipilimumab ...
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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Cell, 2021Francesco Marangoni +2 more
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CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours
Nature, 2021Roberta Zappasodi +2 more
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Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
Cell, 2017Spencer C Wei +2 more
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Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
Cell, 2016Jianjun Gao +2 more
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