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Molecular and Cellular Functions of CTLA-4

, 2020
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T-cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response ...
Samya, Van Coillie, Bartosz, Wiernicki, Jie, Xu   +2 more
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Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

Cancer Cell
Summary Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear.
Evgeny Kiner, Shawn Kothari, Alexander C Huang   +2 more
exaly   +2 more sources

CTLA-4 AT-Repeat Polymorphism Reduces the Inhibitory Function of CTLA-4 in Graves' Disease

Thyroid, 2003
Graves' disease (GD) is thought to be an autoimmune disease with a strong genetic component. Candidate genes include human leukocyte antigen (HLA) class II genes and CTLA-4. The CTLA-4 gene has a variable length AT-repeat polymorphism in the 3'-untranslated region. We previously found that the AT-repeat of 104 bp or longer was associated with GD.
Masaki, Takara, Tsuyoshi, Kouki, Leslie J, DeGroot   +2 more
openaire   +2 more sources

CTLA-4 upregulation during aging

Mechanisms of Ageing and Development, 2002
The immune system gradually becomes anergic with age. Here, we measured intracellular levels of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), a negative regulator of T-cells, in 53 healthy individuals aged 18-94.
Qibin, Leng, Zvi, Bentwich, Gadi, Borkow
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A Native Soluble Form of CTLA-4

Cellular Immunology, 2000
CTLA-4 is an immunoregulatory receptor expressed on the surface of activated T and B lymphocytes. The counterreceptors for CTLA-4 are the B7 family molecules. We describe alternatively spliced mRNAs expressed in hematolymphoid tissues of humans, mice, and rats that lack the transmembrane domain coded by exon 3 of the CTLA-4 gene.
Oaks, Martin, Hallett, Karen, Penwell, R T, Stauber, E C, Warren, S J, Tector, Alfred J   +5 more
openaire   +2 more sources

Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody

Science Translational Medicine, 2014
CTLA-4 blocking antibody induces secondary hypophysitis by binding to CTLA-4 antigen and initiating a type II hypersensitivity reaction.
Shintaro, Iwama, Alessandra, De Remigis, Margaret K, Callahan, Susan F, Slovin, Jedd D, Wolchok, Patrizio, Caturegli   +5 more
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CTLA‐4 gene polymorphisms and natural soluble CTLA‐4 protein in psoriasis vulgaris

International Journal of Immunogenetics, 2006
SummaryCTLA‐4 molecule is an important inhibitor of T‐lymphocyte activation. Several single nucleotide polymorphisms (SNPs) in the CTLA‐4 gene were found, and their associations with many human diseases were described. So far, however, such studies have not been performed in psoriasis vulgaris in Caucasoids.
W, Luszczek, W, Kubicka, M, Jasek, E, Baran, M, Cisło, P, Nockowski, M, Luczywo-Rudy, A, Wiśniewski, I, Nowak, P, Kuśnierczyk   +9 more
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CTLA-4: From mechanism to autoimmune therapy

International Immunopharmacology, 2020
CD28 and CTLA-4 are both important stimulatory receptors for the regulation of T cell activation. Because receptors share common ligands, B7.1 and B7.2, the expression and biological function of CTLA-4 is important for the negative regulation of T cell responses.
Arezoo, Hosseini, Tohid, Gharibi, Faroogh, Marofi, Zohreh, Babaloo, Behzad, Baradaran   +4 more
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Soluble CTLA-4 – A confounding factor in CTLA-4 based checkpoint immunotherapy in cancer

Immunology Letters
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a receptor that inhibits the activity of T cells. The CTLA-4 gene consists of four different exons that enable four different isoforms of CTLA-4 to be generated through alternative splicing. Although sCTLA-4 might impede the therapeutic effect of anti-CTLA-4 treatments, the role of sCTLA-4 in the ...
Parviz Azimnasab-sorkhabi, Maryam Soltani-asl, Musab Bouhajra, Ephraim A. Ansa-Addo, Jose Roberto Kfoury Junior   +4 more
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Reversal of the TCR Stop Signal by CTLA-4

Science, 2006
The coreceptor cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is pivotal in regulating the threshold of signals during T cell activation, although the underlying mechanism is still not fully understood. Using in vitro migration assays and in vivo two-photon laser scanning microscopy, we showed that CTLA-4 increases T cell motility and overrides ...
Schneider, Helga, Downey, Jos, Smith, Andrew, Zinselmeyer, Bemd H., Rush, Catherine, Brewer, James M., Wei, Bin, Hogg, Nancy, Garside, Paul, Rudd, Christopher E.   +9 more
openaire   +4 more sources