Results 51 to 60 of about 1,581 (148)

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

The Genomic Region Encompassing the Nephropathic Cystinosis Gene (CTNS): Complete Sequencing of a 200-kb Segment and Discovery of a Novel Gene within the Common Cystinosis-Causing Deletion [PDF]

Genome Research, 2000
Nephropathic cystinosis is an autosomal recessive disorder caused by the defective transport of cystine out of lysosomes. Recently, the causative gene (CTNS) was identified and presumed to encode an integral membrane protein called cystinosin. Many of the disease-associated mutations inCTNSare deletions, including one >55 kb in size that represents ...
J W, Touchman, Y, Anikster, N L, Dietrich, V V, Maduro, G, McDowell, V, Shotelersuk, G G, Bouffard, S M, Beckstrom-Sternberg, W A, Gahl, E D, Green   +9 more
openaire   +2 more sources

Clinical, biochemical, and molecular spectrum of nephropathic cystinosis: Two novel CTNS mutations

Saudi Journal of Kidney Diseases and Transplantation
Background: Nephropathic cystinosis (NC) is an autosomal recessive disease. Mutations in the CTNS gene encoding the lysosomal membrane cystine transporter cystinosin are identified as the molecular basis of cystinosis.
Zeinab Youssef Abdallah, Rasha Helmy, Walaa S. Nazim, Marwa M. Nabhan, Hanan Abdelaziz, Hala N. Soliman, Ahmed K. Saad, Mona Ibrahim, Amr Sobhi Gouda, Ekram Fateen, Neveen A. Soliman   +10 more
doaj   +1 more source

Don't Cut the Cord: Why Umbilical Cord Blood Still Deserves a Place in Transplantation

International Journal of Immunogenetics, Volume 53, Issue 3, Page 229-239, June 2026.
ABSTRACT The use of umbilical cord blood (UCB) as a stem cell source in haematopoietic stem cell transplant (HSCT) has greatly declined in recent years. It has largely been replaced by mismatched unrelated and family donors, facilitated by advances in transplant technologies, including post‐transplant cyclophosphamide to prevent graft‐versus‐host ...
Jenna Nunn, Kay Poulton, Robert Wynn
wiley   +1 more source

The novel aminoglycoside, ELX-02, permits CTNSW138X translational read-through and restores lysosomal cystine efflux in cystinosis.

PLoS ONE, 2019
BACKGROUND:Cystinosis is a rare disorder caused by recessive mutations of the CTNS gene. Current therapy decreases cystine accumulation, thus slowing organ deterioration without reversing renal Fanconi syndrome or preventing eventual need for a kidney ...
Emma J Brasell, Lee Lee Chu, Murielle M Akpa, Idit Eshkar-Oren, Iris Alroy, Rachel Corsini, Brian M Gilfix, Yojiro Yamanaka, Pedro Huertas, Paul Goodyer   +9 more
doaj   +1 more source

Nephropathic Cystinosis: Symptoms, Treatment, and Perspectives of a Systemic Disease

Frontiers in Pediatrics, 2018
Cystinosis is a rare autosomal recessive lysosomal storage disorder caused by mutations in the CTNS gene. Main dysfunction is a defective clearance of cystine from lysosomes that leads to accumulation of cystine crystals in every tissue of the body ...
Sören Bäumner, Lutz T. Weber
doaj   +1 more source

Recent Advances in the Synthesis and Processing of Carbon Nanotubes and Carbon Nanocomposites for Energy Storage, Biomedical, and Environmental Applications

ChemistryOpen, Volume 15, Issue 5, May 2026.
This review summarizes recent advances in the synthesis and processing of carbon nanotubes and carbon nanocomposites, highlighting structure–property relationships and their applications in energy storage, biomedical systems, and environmental technologies, with emphasis on performance optimization and sustainable material design.
Noor‐ul‐Huda Altaf, Muhammad Ayyaz, Yaning Zhang, Mudassar Shahzad, Ayesha Khan, Sanam, Wasqa Liaqat, Ambreen Ashar, Roshaan Malik, Zeeshan Ahmad Bhutta   +9 more
wiley   +1 more source

Decreased expression of catenins (? and ?), p120 CTN, and E-cadherin cell adhesion proteins and E-cadherin gene promoter methylation in prostatic adenocarcinomas [PDF]

Cancer, 2001
Catenin/E-cadherin complex proteins play an important role in cell-cell adhesion with decreased expression correlating with adverse prognostic variables in several human malignancies.Archival formalin fixed, paraffin embedded (FFPE) sections from 118 prostatic adenocarcinomas (PACs) were immunostained by an automated method (Ventana Medical Systems ...
B V, Kallakury, C E, Sheehan, E, Winn-Deen, J, Oliver, H A, Fisher, R P, Kaufman, J S, Ross   +6 more
openaire   +2 more sources

Differential gene expression in patients with subsyndromal symptomatic depression and major depressive disorder.

PLoS ONE, 2017
BackgroundSubsyndromal symptomatic depression (SSD) is a subtype of subthreshold depressive and can lead to significant psychosocial functional impairment.
Chengqing Yang, Guoqin Hu, Zezhi Li, Qingzhong Wang, Xuemei Wang, Chengmei Yuan, Zuowei Wang, Wu Hong, Weihong Lu, Lan Cao, Jun Chen, Yong Wang, Shunying Yu, Yimin Zhou, Zhenghui Yi, Yiru Fang   +15 more
doaj   +1 more source

Follow‐Up of Children With Primary Ciliary Dyskinesia

Pediatric Pulmonology, Volume 61, Issue 5, May 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder resulting in defective ciliary motility, which leads to a spectrum of clinical manifestations, including chronic upper and lower respiratory infections, middle ear disease, situs abnormalities, congenital heart defects, and infertility.
Bruna Rubbo, Jonathan Wen Yi Ong, William Tsang, Lydia M. Newman, Jane S. Lucas   +4 more
wiley   +1 more source