Results 61 to 70 of about 49,499 (264)

Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy

Frontiers in Neuroscience, 2013
Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by ...
Kristi A Kohlmeier, Christopher J Tyler, Mike eKalogiannis, Masaru eIshibashi, Morten P Kristensen, Iryna eGumenchuk, Richard M Chemelli, Yaz eKisanuki, Masashi eYanagisawa, Christopher S Leonard   +9 more
doaj   +1 more source

The outcomes of electronic personal health records in patients with heart failure or coronary artery disease

ESC Heart Failure, Volume 12, Issue 2, Page 1464-1468, April 2025.
Abstract Background There are limited data on the efficacy of smartphone‐based personal health records (PHRs) in patients with cardiovascular disease. This study aimed to examine the processes, outcomes and challenges associated with the implementation of integrated PHRs in patients with heart failure (HF) or coronary artery disease (CAD). Methods This
Kotaro Nochioka, Satoshi Yasuda, Takashi Shiroto, Saori Yamamoto, Haruka Sato, Yuhi Hasebe, Shigeo Godo, Makoto Nakano, Tomohiko Shindo, Kensuke Nishimiya, Kiyotaka Hao, Jun Takahashi, Keisuke Ido, Yoichi Kakuta, Hiroaki Shimizu, Hiroaki Shimokawa, Masaharu Nakayama   +16 more
wiley   +1 more source

Myocardial mechano-energetic efficiency and insulin resistance in non-diabetic members of the Strong Heart Study cohort

Cardiovascular Diabetology, 2019
Background Myocardial energetic efficiency (MEE), is a strong predictor of CV events in hypertensive patient and is reduced in patients with diabetes and metabolic syndrome.
Costantino Mancusi, Giovanni de Simone, Lyle G. Best, Wenyu Wang, Ying Zhang, Mary J. Roman, Elisa T. Lee, Barbara V. Howard, Richard B. Devereux   +8 more
doaj   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Evaluating governance in a clinical and translational research organization

Journal of Clinical and Translational Science
Institutional Development Awards for Clinical and Translational Research (IDeA-CTR) networks, funded by NIH/NIGMS, aim to advance CTR infrastructure to address historically unmet state and regional health needs.
Ingrid Philibert, Amanda Fletcher, Katrina M. Poppert Cordts, Matthew Rizzo   +3 more
doaj   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

CPM-sensitive AUC for CTR prediction

CoRR, 2019
The prediction of click-through rate (CTR) is crucial for industrial applications, such as online advertising. AUC is a commonly used evaluation indicator for CTR models. For advertising platforms, online performance is generally evaluated by CPM. However, in practice, AUC often improves in offline evaluation, but online CPM does not.
Zhaocheng Liu, Guangxue Yin
openaire   +2 more sources

Effects of LED Light Exposure on Lutein and Bioactive Compounds in Nasturtium Flowers (Tropaeolum majus L.)

Future Postharvest and Food, EarlyView.
Red LED supplementation during cultivation modulated the accumulation of bioactive compounds in Tropaeolum majus flowers. Moderate exposure (3–5 h) enhanced antioxidant capacity and increased carotenoids, phenolics, and anthocyanins depending on petal color, highlighting a simple strategy to improve the functional value of edible flowers. ABSTRACT This
Amanda Lais Alves Almeida Nascimento, Larissa Lorrane Rodrigues Borges, Thaís Caroline Buttow Rigolon, Elder Felipe Silva Roncheti, Márcia Cristina Teixeira Ribeiro Vidigal, Ângela Cristina Oliveira Stringheta, Evandro Martins, Pedro Henrique Campelo, Paulo César Stringheta   +8 more
wiley   +1 more source

Holistic Neural Network for CTR Prediction

Proceedings of the 26th International Conference on World Wide Web Companion - WWW '17 Companion, 2017
This paper proposes HNN, a holistic neural network structure for click-through rate (CTR) prediction in recommender systems. Empirically, equipped with HNN, the performance of deep neural networks for CTR prediction are improved on Criteo and Huawei App Store datasets.
Huifeng Guo, Ruiming Tang, Yunming Ye, Xiuqiang He 0001   +3 more
openaire   +1 more source

J integral computation and Limit load analysis of bonded composite repair in cracked pipes under pressure

Fracture and Structural Integrity, 2019
In this paper, an additional criterion was introduced to evaluate the composite repair systems using the limit load analysis. The plastic collapse pressure of API 5L X65 PSL2 steel pressure vessel structure with crack defect is numerically investigated ...
Mohamed Belhamiani, Djamel Eddine Belhadri, Wahid Oudad, Omar Mansouri, Wahiba Nessrine Bouzitouna   +4 more
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