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CTX-M-33 Is a CTX-M-15 Derivative Conferring Reduced Susceptibility to Carbapenems [PDF]

Antimicrobial Agents and Chemotherapy, 2019
CTX-M-type extended-spectrum β-lactamases (ESBLs) are widespread among Enterobacterales strains worldwide. The most common variant is CTX-M-15, which hydrolyzes ceftazidime at a high rate but spares carbapenems. Here, we identified CTX-M-33, a point mutation derivative of CTX-M-15 (Asp to Ser substitution at Ambler ...
Laurent Poirel, Jose Manuel Ortiz De La Rosa, Marta Aires-de-Sousa   +2 more
exaly   +4 more sources

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The CTX-M β-lactamase pandemic

Current Opinion in Microbiology, 2006
In the past decade CTX-M enzymes have become the most prevalent extended-spectrum beta-lactamases, both in nosocomial and in community settings. The insertion sequences (ISs) ISEcp1 and ISCR1 (formerly common region 1 [CR1] or orf513) appear to enable the mobilization of chromosomal beta-lactamase Kluyvera species genes, which display high homology ...
Rafael Cantón, Teresa M Coque
exaly   +3 more sources

Prevalence of O25b-ST131 clone amongEscherichia colistrains producing CTX-M-15, CTX-M-14 and CTX-M-92 β-lactamases

Infectious Diseases, 2016
Dissemination of multidrug-resistant Escherichia coli is closely associated with the worldwide spread of a single clone ST131, which is the main cause of urinary tract and bloodstream infections in patients from nursing homes and immunocompromised patients.
Giedraitienė, Agnė, Vitkauskienė, Astra, Pavilonis, Alvydas, Patamsytė, Vaiva, Genel, Nathalie, Decré, Dominique, Arlet, Guillaume   +6 more
openaire   +2 more sources

Biochemical characterisation of the CTX-M-14 β-lactamase

International Journal of Antimicrobial Agents, 2007
Cefotaxime-resistant Escherichia coli TUM1121 was isolated from an abscess of an 83-year-old patient. The CTX-M-14 gene was located on a 70 kb plasmid. The enzyme was purified and its activity was analysed. CTX-M-14 was poorly active against ceftazidime and aztreonam. Aztreonam behaved as a competitive inhibitor. Among the tested suicide substrates for
Ishii, Y., Galleni, Moreno, Ma, L., Frère, Jean-Marie, Yamaguchi, K.   +4 more
openaire   +2 more sources

bla(CTX-M) Genes in Escherichia coli Strains from Croatian Hospitals Are Located in New (bla(CTX-M-3a)) and Widely Spread (bla(CTX-M-3a) and bla(CTX-M-15)) Genetic Structures

Antimicrobial agents and chemotherapy, 2009
CTX-M-producing Escherichia coli isolates from three Croatian hospitals were analyzed. All blaCTX-M-15 and one blaCTX-M-3a genes resided in widely-spread ISEcp1 transposition modules but other blaCTX-M-3a genes were in a new configuration with two IS26 copies, indicating a new event of gene mobilization from a Kluyvera ascorbata genome.
Bedenić, Branka, Jajić, Ines, Tonkić, Marija   +2 more
openaire   +2 more sources

High prevalence of CTX-M-15 and first report of CTX-M-3, CTX-M-22, CTX-M-28 and plasmid-mediated AmpC beta-lactamase producing Enterobacteriaceae causing urinary tract infections in Bosnia and Herzegovina in hospital and community settings

Journal of Infection and Chemotherapy, 2015
To investigate molecular epidemiology of extended-spectrum β-lactamase/ESBL and plasmid-mediated AmpC β-lactamase/pAmpC producing Gram-negative bacteria causing urinary tract infections (UTIs) in Zenica-Doboj Canton, Bosnia and Herzegovina, in the period Decembar 2009-May 2010.Antibiotic susceptibility was determined by disc diffusion and broth ...
Amir Ibrahimagić, Branka Bedenić, Farah Kamberović, Selma Uzunović   +3 more
openaire   +4 more sources

Biochemical characterization of CTX-M-166, a new CTX-M β-lactamase produced by a commensal Escherichia coli isolate

The Journal of Antibiotics, 2017
We thank Fundacao para a Ciencia e a Tecnologia (FCT) for project grant PEst-OE/AGR/UI0211/2011–2014, Strategic Project UI211-2011-2014. VM was supported by FCT fellowship (grant SFRH/BPD/77486/2011), financed by the European Social Funds (COMPETE-FEDER) and national funds of the Portuguese Ministry of Education and Science (POPH-QREN)
Manageiro, Vera, Graça, Rafael, Ferreira, Eugénia, Clemente, Lurdes, Bonnet, Richard, Caniça, Manuela   +5 more
openaire   +4 more sources

O204 Ceftazidime resistance evolution in ESBLs belonging to CTX-M-1 cluster (CTX-M-1, CTX-M-3, CTX-M-10) in a hypermutator background

International Journal of Antimicrobial Agents, 2007
A. Novais, R. Cantón, R. Moreira, T.M. Coque, F. Baquero, J.C. Galán   +5 more
openaire   +1 more source

Interaction of carbapenems and Î2-lactamase inhibitors towards CTX-M-15 and CTX-M-15G238Cmutant

2017
Objectives The aim of this study was to evaluate the role of residue 238 in CTX-M-15 and CTX-M-15G238Cmutant with respect to carbapenems and various Î2-lactamase inhibitors. Methods A CTX-M-15G238Claboratory mutant was generated by site-directed mutagenesis from CTX-M-15 enzyme by replacing glycine 238 with cysteine.
Sabatini, Alessia, Brisdelli, Fabrizia, Celenza, Giuseppe, Marcoccia, Francesca, Colapietro, Martina, Tavío, María M., Piccirilli, Alessandra, Amicosante, Gianfranco, Perilli, Mariagrazia   +8 more
openaire   +1 more source