Results 151 to 160 of about 16,034 (193)
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Hexanor–cucurbitacin D, a degraded cucurbitacin from Begoniatuberhybrida var. alba
Canadian Journal of Chemistry, 1970A compound isolated from Begoniatuberhybrida has been shown to have the structure of hexanor–cucurbitacin D (3). Its diacetate is identical to the neriodate cleavage product of cucurbitacin B diacetate.
Raymond W. Doskotch, Charles D. Hufford
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A New Cucurbitacin D Related 16,23-Epoxy Derivative and Its Isomerization Products
Organic Letters, 2004[reaction: see text] A new (23S,24Z)-16,23-epoxy cucurbitacin derivative was isolated from Ecballium elaterium L. (Cucurbitaceae) fruit juice along with known cucurbitacin derivatives. Structure elucidation of these derivatives was accomplished by NMR spectroscopy and mass spectrometry from HPLC-MS data.
Christoph, Seger +3 more
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Monatshefte für Chemie - Chemical Monthly, 2005
1H and 13C NMR signal assignments derived from 2D NMR experiment based correlations are presented for 22-deoxocucurbitacin D and cucurbitacin D. Both derivatives have been isolated from Ecballium elaterium L. (Cucurbitaceae).
Christoph Seger +3 more
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1H and 13C NMR signal assignments derived from 2D NMR experiment based correlations are presented for 22-deoxocucurbitacin D and cucurbitacin D. Both derivatives have been isolated from Ecballium elaterium L. (Cucurbitaceae).
Christoph Seger +3 more
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Abstract 3224: Cucurbitacin D inhibits prostate tumor growth via targeting glucose metabolism
Cancer Research, 2017Abstract Background: Emergence of hormone-refractory PrCa (HRPC) after the anti-androgen therapy, cancer metastasis and chemo-resistance are the major hurdle for the treatment of prostate cancer (PrCa) patients. Accumulative evidence suggests that altered glucose metabolism is one of the mechanisms for metastatic PrCa cell survival and ...
Mohammed Sikander +7 more
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Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells
Medical Oncology, 2016We previously reported that the inflammasome inhibitor cucurbitacin D (CuD) induces apoptosis in human leukemia cell lines. In the present study, we investigated the effects of co-treatment with an additional Bcl-xL inhibitor, Z36. Treatment with Z36 induced cell death in leukemia cell lines, with MT-4 cells exhibiting the lowest sensitivity to Z36. Co-
Tsukasa, Nakanishi +7 more
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Model studies directed to the synthesis of cucurbitacin I C/D rings
Tetrahedron Letters, 2015Abstract Herein, we detail a synthetic strategy toward the C/D rings of cucurbitacin I, a naturally occurring triterpenoid. This route utilized ring-opening/ring-closing metathesis of a norbornene derivative for the formation of the C/D ring advanced intermediates, allowing for stereocontrol of the chiral centers.
Nicholas A. Eddy, Gabriel Fenteany
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Cucurbitacin D Inhibits NF-κB Activation, Thereby Inducing Apoptosis and Suppressing Tumor Growth
The Frontiers of Society, Science and Technology, 2021Recently, more and more researchers are investigating the effectiveness of using traditional Chinese medicine as a treatment to treat cancer. This work investigates the Cucurbitacin D, an active component found in the traditional Chinese medicine Trichosanthes kirilowii tuber.
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Blood, 2007
Abstract The search for novel therapeutic candidates causing reactivation of fetal hemoglobin (a2g2; HbF) to reduce the imbalance of globin gene expression is important in order to develop effective approach for the clinical management of sickle cell anemia and b-thalassemia. For the first time, we have identified cucurbitacin D (CuD), a
Ming Chiu Fung +3 more
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Abstract The search for novel therapeutic candidates causing reactivation of fetal hemoglobin (a2g2; HbF) to reduce the imbalance of globin gene expression is important in order to develop effective approach for the clinical management of sickle cell anemia and b-thalassemia. For the first time, we have identified cucurbitacin D (CuD), a
Ming Chiu Fung +3 more
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Journal of Invertebrate Pathology, 1996
In vitro assays were conducted to determine the effect of cucurbitacin D, an oxygenated tetracyclic triterpenoid found in cucurbits, on the growth of Xenorhabdus isolated from Steinernema carpocapsae (All, Mexican, Agriotos strains), Steinernema riobravis, Steinernema glaseri (NC strain, strain 27), and Photorhabdus from Heterorhabditis bacteriophora ...
M E, Barbercheck, J, Wang
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In vitro assays were conducted to determine the effect of cucurbitacin D, an oxygenated tetracyclic triterpenoid found in cucurbits, on the growth of Xenorhabdus isolated from Steinernema carpocapsae (All, Mexican, Agriotos strains), Steinernema riobravis, Steinernema glaseri (NC strain, strain 27), and Photorhabdus from Heterorhabditis bacteriophora ...
M E, Barbercheck, J, Wang
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International Immunopharmacology, 2009
The aim of the present study is to examine the effects of the anti-tumor component isolated from Trichosanthes kirilowii on human hepatocellular carcinoma cells. Using Sephadex G-25 column chromatography, Sep-Pak Plus C18 cartridge and high-performance liquid chromatography (HPLC), we isolated the active component from trichosanthes extract.
Norito, Takahashi +5 more
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The aim of the present study is to examine the effects of the anti-tumor component isolated from Trichosanthes kirilowii on human hepatocellular carcinoma cells. Using Sephadex G-25 column chromatography, Sep-Pak Plus C18 cartridge and high-performance liquid chromatography (HPLC), we isolated the active component from trichosanthes extract.
Norito, Takahashi +5 more
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