Results 161 to 170 of about 16,034 (193)
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Cancer Research, 2023
Abstract Background: Accumulating studies have shown strong correlation of HCC and co-morbidity factors including smoking. Tobacco smoke contains benzo[a]pyrene, which is extremely carcinogenic and contributes to liver damage. Cucurbitacin, a triterpene, has a wide range of biological activities, including antioxidant, anti-inflammatory,
Shabnam Malik +6 more
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Abstract Background: Accumulating studies have shown strong correlation of HCC and co-morbidity factors including smoking. Tobacco smoke contains benzo[a]pyrene, which is extremely carcinogenic and contributes to liver damage. Cucurbitacin, a triterpene, has a wide range of biological activities, including antioxidant, anti-inflammatory,
Shabnam Malik +6 more
openaire +1 more source
Insect Biochemistry, 1988
Four glucosidic products of the metabolism of dietary cucurbitacins were isolated from whole body extracts of field collected Diabrotica undecimpunctata howardi Barber by preparative HPLC. These were identified on the basis of mass and 13C NMR spectral data as 23,24-dihydrocucurbitacin I-2-O-d-glucoside (1), 23,24-dihydrocucurbitacin 2-O-d-glucoside (2)
J.F. Andersen +2 more
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Four glucosidic products of the metabolism of dietary cucurbitacins were isolated from whole body extracts of field collected Diabrotica undecimpunctata howardi Barber by preparative HPLC. These were identified on the basis of mass and 13C NMR spectral data as 23,24-dihydrocucurbitacin I-2-O-d-glucoside (1), 23,24-dihydrocucurbitacin 2-O-d-glucoside (2)
J.F. Andersen +2 more
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Investigational New Drugs, 2020
Adult T cell leukemia (ATL) is an aggressive and malignant blood disease. We previously reported that steroid-structured cucurbitacin D (CuD) induces apoptosis in ATL cells. In this study, we investigated the effects of mitogen-activated protein kinase (MAPK) signaling inhibitors on CuD-induced cell death in peripheral blood lymphocytes (PBLs) isolated
Duo Wang +7 more
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Adult T cell leukemia (ATL) is an aggressive and malignant blood disease. We previously reported that steroid-structured cucurbitacin D (CuD) induces apoptosis in ATL cells. In this study, we investigated the effects of mitogen-activated protein kinase (MAPK) signaling inhibitors on CuD-induced cell death in peripheral blood lymphocytes (PBLs) isolated
Duo Wang +7 more
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Cancer Research, 2016
Abstract Background: Cervical cancer is one of the leading cause of mortality among women in US. Naturally occurring dietary compounds have gained increasing attention for their anticancer effects. Cucurbitacins, tetracyclic triterpenoid compound, belong to a family of Cucurbitaceae have shown promising anti-cancer activity.
Mohammed Sikander +5 more
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Abstract Background: Cervical cancer is one of the leading cause of mortality among women in US. Naturally occurring dietary compounds have gained increasing attention for their anticancer effects. Cucurbitacins, tetracyclic triterpenoid compound, belong to a family of Cucurbitaceae have shown promising anti-cancer activity.
Mohammed Sikander +5 more
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Cancer Research, 2018
Abstract Background: Docetaxel (DTX) is an FDA approved drug for the treatment of advanced prostate cancer (PrCa). However, chemo-resistance and toxicity limits its use in clinic. Accumulating evidence suggests that activation of cancer stem cells (CSCs) is one of the mechanisms leading to developing chemo-resistance Therefore ...
Mohammed Sikander +6 more
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Abstract Background: Docetaxel (DTX) is an FDA approved drug for the treatment of advanced prostate cancer (PrCa). However, chemo-resistance and toxicity limits its use in clinic. Accumulating evidence suggests that activation of cancer stem cells (CSCs) is one of the mechanisms leading to developing chemo-resistance Therefore ...
Mohammed Sikander +6 more
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Cucurbitacin D from Cercidiphyllum japonicum
Biochemical Systematics and Ecology, 1997Satyajit D. Sarker +4 more
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Cucurbitacin D: An Innovative Approach for Metastatic Prostate Cancer Treatment
2022Sikander, Mohammed +3 more
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Microbial Transformation of Cucurbitacin E 2-O-β-D-Glucopyranoside
Journal of Natural Products, 1995Galal Maatooq +3 more
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Communications in agricultural and applied biological sciences, 2004
A trap is described that uses as a simple natural ingredient a cucurbitacin mixture to capture and carbaryl insecticide to kill northern and western corn rootworm beetles (Diabrotica barberi Smith and Lawrence, and Diabrotica virgifera virgifera LeConte (D.v.v.), respectively). The trap is consistent in numbers of beetles captured per trap per day, and
J T, Shaw, H E, Hummel
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A trap is described that uses as a simple natural ingredient a cucurbitacin mixture to capture and carbaryl insecticide to kill northern and western corn rootworm beetles (Diabrotica barberi Smith and Lawrence, and Diabrotica virgifera virgifera LeConte (D.v.v.), respectively). The trap is consistent in numbers of beetles captured per trap per day, and
J T, Shaw, H E, Hummel
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Selective inhibition of thymidine incorporation into lymphocytes by cucurbitacins B and D
Biochemical Pharmacology, 1969M W, Whitehouse, R W, Doskotch
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