Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo [PDF]
Integrative Cancer TherapiesChemotherapy-induced peripheral neuropathy (CIPN) has a markedly deleterious impact on a patient’s quality of life. It manifests as pain, paresthesia, numbness, and weakness, particularly in the context of cisplatin (CDDP), a widely utilised ...
Sooyeon Kang +5 more
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Macedonian Journal of Chemistry and Chemical Engineering, 2019 The objective of this study was to develop a rapid, economic, and efficient method for simultaneous selective isolation, separation, and purification of cucurbitacin D and I from Ecballium elaterium (L.) A.
Emir Tosun, Ahmet Baysar
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Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling [PDF]
International Journal of Immunopathology and Pharmacology, 2018 Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities.
Jin Mo Ku +8 more
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Induction of AHR Gene Expression in Colorectal Cancer Cell Lines by Cucurbitacin D, E, and I [PDF]
Journal of Cell and Molecular Research, 2019 Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and its induction may result in suppressing of cell proliferation in colorectal cancer (CRC).
Younes Aftabi +4 more
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Indonesian Journal of Chemistry, 2020 Benalu batu (Begonia sp.) had been used traditionally as an anticancer medicinal plant by Wana tribe in Morowali, Central Sulawesi, This study aims to evaluate the cytotoxic activity of 2-O-β-glucopyranosil cucurbitacin D, isolated from the ethyl acetate
Muhammad Sulaiman Zubair +4 more
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Pharmacokinetic Profile of Extracts from the Chayote (Sechium edule) H387 07 Hybrid and Phytochemical Characterization of Its Segregant H387 M16 for Potential Therapeutic Applications [PDF]
MoleculesThe hybrid Sechium edule H387 07, commonly known as chayote, has shown potential as an antiproliferative, cytotoxic, and pro-apoptotic agent in the murine leukemia cell lines P388 (macrophagic) and J774 (monocytic) and in the myelomonocytic leukemia cell
Eugenia Elisa Delgado-Tiburcio +6 more
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Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. [PDF]
Cancers (Basel), 2019 Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc
Sikander M +11 more
europepmc +4 more sources
Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. [PDF]
J Nat Prod, 2015 Heat shock protein 90 (Hsp90) facilitates the maturation of many newly synthesized and unfolded proteins (clients) via the Hsp90 chaperone cycle, in which Hsp90 forms a heteroprotein complex and relies upon cochaperones, immunophilins, etc., for assistance in client folding. Hsp90 inhibition has emerged as a strategy for anticancer therapies due to the
Hall JA +5 more
europepmc +4 more sources
Cucurbitacin D Induces G2/M Phase Arrest and Apoptosis via the ROS/p38 Pathway in Capan-1 Pancreatic Cancer Cell Line. [PDF]
Evid Based Complement Alternat Med, 2020 Pancreatic cancer has a poor prognosis with a five‐year survival rate of less than 10%. Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity. Therefore, the development of effective therapeutic strategies and novel drugs against pancreatic cancer is an urgent need. Cucurbitacin D (CuD), a plant steroid
Kim MS +7 more
europepmc +3 more sources
Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula)
Frontiers in Plant Science, 2022 Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. However, there is no comprehensive analysis of cucurbitacin biosynthesis in Luffa fruit.
Gangjun Zhao +9 more
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