Results 161 to 170 of about 15,560 (192)

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

Phytomedicine, 2019
Cucurbitacin E (CuE) is an oxygenated tetracyclic triterpenoid isolated from the fruits of Citrullus colocynthis (L.) Schrad.This study outlines CuE's cytotoxic activity against drug-resistant tumor cell lines. Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated ...
Mohamed E.M. Saeed, Joelle C. Boulos, Gihan Elhaboub, Daniela Rigano, Antoine Saab, Monica R. Loizzo, Loiy E.A. Hassan, Yoshikazu Sugimoto, Sonia Piacente, Rosa Tundis, Sakina Yagi, Hassan Khalid, Thomas Efferth   +12 more
openaire   +5 more sources

Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling

Journal of Agricultural and Food Chemistry, 2020
Chemoresistance and toxicity are the main obstacles that limit the efficacy of 5-fluorouracil (5-FU) in colorectal cancer (CRC) therapy. Hence, it is urgent to identify new adjuvants that can sensitize CRC cells to conventional chemotherapeutic approaches.
Peng Yang, Wen Liu, Rong Fu, Guo-bin Ding, Sajid Amin, Zhuoyu Li   +5 more
openaire   +2 more sources

Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion

Breast Cancer Research and Treatment, 2012
Tumor metastasis is the main cause of cancer-related deaths of patients. Breast cancer is highly malignant with considerable metastatic potential, which urges the necessity for developing novel potential drug candidate to prevent tumor metastasis. Here, we report our finding with Cucurbitacin E (CuE, α-elaterin), a tetracyclic triterpenes compound ...
Tao, Zhang, Jingjie, Li, Yanmin, Dong, Dong, Zhai, Li, Lai, Fujun, Dai, Huayun, Deng, Yihua, Chen, Mingyao, Liu, Zhengfang, Yi   +9 more
openaire   +2 more sources

Preparation and characterization of liposomes incorporating cucurbitacin E, a natural cytotoxic triterpene

International Journal of Pharmaceutics, 2013
Cucurbitacin E (Cuc E), highly oxygenated triterpene from cucurbitaceae family, was demonstrated to possess anti-proliferative, anti-inflammatory and anti-oxidant activities. Here, we studied the effect of Cuc E on the properties of the phospholipid membrane.
Lamice, Habib, Nathalie, Khreich, Alia, Jraij, Suzanne, Abbas, Jacques, Magdalou, Catherine, Charcosset, Hélène, Greige-Gerges   +6 more
openaire   +2 more sources

Cucurbitacin E and I in Iberis amara: Feeding inhibitors for Phyllotreta nemorum

Phytochemistry, 1977
Abstract Cucurbitacin E and cucurbitacin I have been isolated from green parts of Iberis amara and identified by TLC, UV and MS. It is shown that cucurbitacins act as feeding inhibitors for the flea beetle Phyllotreta nemorum. The most potent feeding inhibitors in green parts of I. amara towards P.
Jens Kvist Nielsen, Lone Melchior Larsen, Hilmer Søorensen   +2 more
exaly   +2 more sources

Ultrasound-assisted supercritical CO2 extraction of cucurbitacin E from Iberis amara seeds

Industrial Crops and Products, 2020
Abstract Cucurbitacin E (CuE) is an active compound with heterogeneous biological activity and is abundant in Iberis amara seeds. To extract CuE from the seeds, a novel procedure using ultrasound-assisted supercritical CO2 extraction (UASCE) was exploited in this study.
Xing-yu Liu, Hong Ou, Hans Gregersen
openaire   +1 more source

Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling

Journal of Cancer Research and Clinical Oncology, 2009
Pancreatic cancer has been a serious disease worldwide for its high mortality. Cucurbitacin E is a member of triterpenoid family isolated from plants showing antiproliferative activity on various cancer cells. In this study, we have explored whether cucurbitacin E also has an anti-tumor effect on pancreatic cancer cells.Human pancreatic cancer cells ...
Chunyan, Sun, Meixia, Zhang, Xiaolei, Shan, Xueying, Zhou, Jiao, Yang, Yanli, Wang, Jesse, Li-Ling, Yihui, Deng   +7 more
exaly   +3 more sources

Stability of cucurbitacin E in human plasma: chemical hydrolysis and role of plasma esterases

Biopharmaceutics & Drug Disposition, 2009
AbstractIt was shown previously that the anticancerous cytotoxic oxygenated triterpenes, cucurbitacin E (Cuc E) and its deacetylated form, cucurbitacin I (Cuc I), interacted differently with human serum albumin.In this study, the biochemical stability of Cuc E was investigated in vitro by reverse‐phase high performance liquid chromatography.
Myriam, Saade, Jacques, Magdalou, Naim, Ouaini, Helene, Greige-Gerges   +3 more
openaire   +2 more sources

Cucurbitacin-E Inhibits Multiple Cancer Cells Proliferation Through Attenuation of Wnt/β-Catenin Signaling

Cancer Biotherapy and Radiopharmaceuticals, 2014
Recent studies suggest that the use of cucurbitacins could inhibit cancer cell progression. In the current study, the authors analyzed the effect of cucurbitacin-E (CuE) in cancer cells using A549, Hep3B, and SW480 cells. The authors found that CuE inhibited cell proliferation and modulated the expression of cell cycle regulators in these cells ...
Hui, Feng, Li, Zang, Zhen-Xia, Zhao, Quan-Cheng, Kan   +3 more
openaire   +2 more sources

Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells

Bioorganic & Medicinal Chemistry Letters, 2010
Cucurbitane-type triterpenes, cucurbitacins B and E, were reported to exhibit cytotoxic effects in several cell lines mediated by JAK/STAT3 signaling. However, neither compound inhibited phosphorylation of STAT3 in human leukemia (U937) cells at low concentrations. We therefore synthesized a biotin-linked cucurbitacin E to isolate target proteins based
Souichi, Nakashima, Hisashi, Matsuda, Ai, Kurume, Yoshimi, Oda, Seikou, Nakamura, Masayuki, Yamashita, Masayuki, Yoshikawa   +6 more
openaire   +2 more sources