Results 181 to 190 of about 14,776 (215)
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Anti-Inflammatory and Analgesic Effects of Cucurbitacins fromWilbrandia ebracteata
Planta Medica, 1997The anti-inflammatory and antinociceptive actions of the CH2Cl2 extract and semipurified fraction (F-III) from roots of Wilbrandia ebracteata Cogn. have been investigated in rats and mice. The CH2Cl2 extract (1-10 mg/kg, i.p.; ID50 5 mg/kg) and (3-30 mg/kg, p.o.; ID50 15 mg/kg) inhibited, in a dose-related manner, carrageenan-induced paw edema in rats.
R R, Peters +2 more
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Anti-Inflammatory Activity of Two Cucurbitacins Isolated fromCayaponia tayuyaRoots
Planta Medica, 2004Fractionation of an anti-inflammatory extract from Cayaponia tayuya roots yielded two active compounds, identified as 23,24-dihydrocucurbitacin B (1) and cucurbitacin R (2). Both were evaluated for their anti-inflammatory activity on several experimental models of pain and inflammation.
M Carmen, Recio +7 more
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New Cytotoxic Cucurbitacins from the Pericarps ofTrichosanthes TricuspidataFruits
Natural Product Letters, 2002An extract of the fruits of Trichosanthes tricuspidata collected in North Vietnam was found cytotoxic in KB cells. A bioassay-guided fractionation led to the isolation of a series of cucurbitacins of which two are new: tricuspidatin and 2-O-glucocucurbitacin J. Their isolation and structure determination are described.
Le Phuong, Mai +5 more
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Inhibition of T-Lymphocyte Proliferation by Cucurbitacins from Picrorhiza scrophulariaeflora
Journal of Natural Products, 2000Two cucurbitacin aglycons were isolated from the dried rhizomes of Picrorhiza scrophulariaeflora and were identified as 25-acetoxy-2,3, 16,20-tetrahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (picracin, 1) and 2,3,16,20,25-pentahydroxy-9-methyl-19-norlanosta-5, 23-dien-22-one (deacetylpicracin, 2). Both compounds inhibit mitogen-induced T-lymphocyte
Smit, H.F. +6 more
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Die Pharmazie, 2008
"Hedgehyssop" Gratiola officinalis L. (Scrophulariaceae) is found as an ingredient in homeopathic remedies. Among the active compounds found in G. officinalis, the cucurbitacines constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity.
Melzig, M. F., Kaya, G. I.
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"Hedgehyssop" Gratiola officinalis L. (Scrophulariaceae) is found as an ingredient in homeopathic remedies. Among the active compounds found in G. officinalis, the cucurbitacines constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity.
Melzig, M. F., Kaya, G. I.
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The cellular activity of cucurbitacin I is inhibited by glycosylation
Planta Medica, 2014Cucurbitacins are a class of natural compounds known for their numerous potential pharmacological effects. The purpose of this work was to compare the effects of cucurbitacin glucosides and their aglycone counterparts on the human epithelial carcinoma cell line (HeLa).
Hassoun, Ms +8 more
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Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway
Journal of Cellular Biochemistry, 2018AbstractEndoplasmic reticulum stress (ERS) is usually involved in tumor development and progression, and anticancer agents have recently been recognized to induce ERS. Cucurbitacin‐I showed a potent anticancer action by inducing apoptosis through the inhibition of signal transducer and activator of transcription 3 pathway and triggering autophagic cell
He Li +10 more
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Separation of Cucurbitacins by Overpressure Layer Chromatography fromHemsleya gigantha1
Planta Medica, 1988Mixtures of cucurbitacins were obtained from an ethanol extract of H. GIGANTHA tubers. Purification was achieved by using the over-pressure layer chromatographic (OPLC) technique to yield cucurbitacin-F, 23,24-dihydrocucurbitacin-F, cucurbitacin-F-25- O-acetate, and 23,24-dihydrocucurbitacin-F-25- O-acetate.
P, Yang, H, Wang, W, Chang, C T, Che
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Cucurbitacins and predation of the spotted cucumber beetle, Diabrotica undecimpunctata howardi
Entomologia Experimentalis et Applicata, 1984AbstractTwo hypotheses about the relationship of diabroticina beetles and plants in the family Cucurbitaceae are tested: (1) evolution of sensory receptors for cucurbitacins by diabroticina beetles was in part due to the predator protection offered by ingestion of these compounds, and (2) commercial varieties of cucurbitacin‐producing cucumber offer ...
Fred Gould, Adrianne Massey
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Structurally Interesting Cucurbitacins fromFevillea cordifollia
Planta Medica, 1990L. Johnson +4 more
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