Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats [PDF]
BMC Complementary and Alternative Medicine, 2019 Background Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity.
Natthaphon Hunsakunachai +4 more
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Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents [PDF]
Molecules, 2018 Cucurbitacin B shows potent activity against tumor cells, but its high toxicity limits its application in the clinic. A series of cucurbitacin B derivatives was synthesized and evaluated for their anti-hepatocellular carcinoma (HCC) activities against ...
Weizhi Ge +8 more
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Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities [PDF]
MoleculesThe emergence of natural products has provided extremely valuable references for the treatment of various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is the most abundant member of the ...
Wenzhe Nie +9 more
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Impact of the secondary plant metabolite Cucurbitacin B on the demographical traits of the melon aphid, Aphis gossypii [PDF]
Scientific Reports, 2018 Cucurbitacin B is a natural triterpene present in plants of Cucurbitaceae family, which are among the host plants for melon aphid, Aphis gossypii. In present study we characterized the effects of two cucurbitacin B concentrations on the biological ...
Hafiz Kamran Yousaf +7 more
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Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein [PDF]
Integrative Cancer Therapies, 2022 Owing to the crucial role of Src in cancer metastasis, interruption of Src and its signaling has been considered a promising strategy for cancer metastasis treatment.
Putthaporn Kaewmeesri MS +5 more
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The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells. [PDF]
PLoS ONE, 2013 Cucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrobial ...
Moltira Promkan +4 more
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Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy [PDF]
International Journal of Nanomedicine, 2022 Tingting Chen,1,2,* Bingxiang Ma,1,2,* Shi Lu,1,2 Lupeng Zeng,1,2 Huaying Wang,1,2 Wanhua Shi,1,2 Linying Zhou,3 Yaokun Xia,4 Xi Zhang,1 Jing Zhang,5 Jinghua Chen1 1School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, 350108 ...
Chen T +10 more
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Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice [PDF]
International Journal of Immunopathology and PharmacologyObjective: Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited treatment options and associated side effects or resistance. This study aims to investigate the therapeutic potential of the natural compound cucurbitacin B (CuB) in RA ...
Shu-Ping Kung +5 more
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Preparation, characterization and pharmacokinetics of Cucurbitacin B solid dispersion
OpenNano, 2022 Cucurbitacin B (CuB) is a type of tetracyclic triterpenoids derived from the Cucurbitaceae melon, which has various biological activities. However, the poor water solubility and low bioavailability of CuB limit its wide range of clinical applications ...
Qian Wu +6 more
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Cucurbitacin B suppresses glioblastoma via the STAT3/ROS/endoplasmic reticulum stress pathway [PDF]
Scientific ReportsCucurbitacin B (CuB), the tetracyclic triterpenoid compound belonging to cucurbitaceae family, demonstrates significant anticancer properties across various tumor types.
Guangyao Lv +8 more
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