Cucurbitacins B, E and I Concentrations and Relationship with Drought Tolerance in Bottle Gourd [Lagenaria siceraria (Molina) Standl.] [PDF]
Plants, 2023 Bottle gourd [Lagenaria siceraria (Molina) Standl.]) is a relatively drought-tolerant cucurbit due to the high composition of unique biochemical compositions, including cucurbitacin.
Phumzile Mkhize +2 more
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Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics
Pharmacological Research, 2023 Cucurbitacin B (CuB, C32H46O8), the most abundant and active member of cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely distributed in a variety of plants and mainly isolated from plants in the Cucurbitaceae family. CuB is mostly obtained from the pedicel of Cucumis melo L. Modern pharmacological studies have
Shu, Dai +7 more
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Ecotoxicology and Environmental Safety, 2022 Pesticides are widely used in melon production causing safety issues around the consumption of melon and increasing pathogen and insect tolerance to pesticides.
Lu Kang +6 more
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Cucurbitacin B exerts neuroprotection in a murine Alzheimer’s disease model by modulating oxidative stress, inflammation, and neurotransmitter levels [PDF]
Frontiers in Bioscience-Landmark, 2022 Background: Alzheimer’s disease (AD) type dementia encompasses diverse cognitive deficits marked by free radicals and pro-inflammatory cytokines mediated progressive neurodegeneration and vascular damage including the blood-brain barrier.
Zhiyong Liu, Manish Kumar, Atul Kabra
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VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation. [PDF]
PLoS ONE, 2014 Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis.
Yan-Ting Zhang +8 more
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Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth [PDF]
Translational OncologyBackground: Pyroptosis, a form of programmed cell death, has been shown to induce anti-tumour immunity and inhibit tumour growth. Oral squamous cell carcinoma (OSCC), a prevalent malignant tumour, could benefit from pyroptosis induction as a therapeutic ...
Xin Chen +9 more
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Induction of the STING-dependent DNA damage pathway by cucurbitacin B enhances immunotherapy efficacy in osteosarcoma [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Osteosarcoma (OS) is a highly aggressive bone tumor with limited therapeutic options. Cucurbitacin B (CuB), a natural compound derived from Cucurbitaceae plants, has demonstrated antitumor activity in various malignancies; however, its ...
Bin Luo +5 more
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Improvement of Cucurbitacin B Content in Cucumis melo Pedicel Extracts by Biotransformation Using Recombinant β-Glucosidase [PDF]
Separations, 2021 For the efficient biotransformation of cucurbitacin B 2-o-β-d-glucoside (CuBg) to cucurbitacin B (CuB) in Cucumis melo pedicel extracts, the β-glucosidase gene bglS—consisting of 1344 bp (447 amino acids) from Streptomyces sp.
Jianfeng Mei +5 more
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Corrigendum: Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells. [PDF]
Front Pharmacol, 2023 Alafnan A +3 more
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Chloroform Fraction of Cucumis melo L. ‘Gama Melon Parfum’ Cytotoxicity against Breast Cancer Cell T47D and MCF7 [PDF]
BIO Web of Conferences, 2022 Nature is the source of various types of phytochemicals. Some of them are unique chemical compounds only found in certain plants. For example, Cucurbitacin is found in the family Cucurbitaceae.
Salamah Rohmi, Widiyanto Slamet
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