Bioassay-guided isolation of cytotoxic constituents from the flowers of Aquilaria sinensis
Natural Products and Bioprospecting, 2022 Bioassay-guided fractionation of the EtOH extract from the flowers of Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae) led to the isolation of a new cucurbitane-type triterpenoid, aquilarolide A (1), along with five known compounds (2–6). The structure
Jun Yang +5 more
doaj +1 more source
Migrastatics—anti-Metastatic and Anti-invasion Drugs:Promises and Challenges [PDF]
, 2017 In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing.
Gandalovičová, Aneta +9 more
core +1 more source
Inhibitory Activity of Leaves Extracts of Citrullus colocynthis Schrad. on HT29 Human Colon Cancer Cells [PDF]
, 2016 Aims: Citrullus colocynthis is a plant endemic in Asia, Africa and in the Mediterranean basin. It is used in folk medicine against infections, inflammations and cardiovascular and immune-related diseases.
Aouni, M +8 more
core +1 more source
Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells
Tumor Biology, 2017 In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used.
Si Hyoung Kim +6 more
doaj +1 more source
Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B. [PDF]
Animal Model Exp Med, 2023 Niu B +8 more
europepmc +3 more sources
Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives
Bioorganic & Medicinal Chemistry, 2012 Two cucurbitacins, dihydrocucurbitacin B (1) and cucurbitacin B (2), which can be obtained in large amounts from the roots of Wilbrandia ebracteata and from the fruits of Luffa operculata, respectively, were used as starting materials for the preparation of a library of 29 semi-synthetic derivatives.
Lang, Karen Luise +13 more
openaire +2 more sources
Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade [PDF]
, 2016 OBJECTIVE: Acquired chemoresistance is a major obstacle in the clinical management of ovarian cancer. Therefore, searching for alternative therapeutic modalities is urgently needed.
Al Rawahi T +12 more
core +3 more sources
Journal of Chemistry, 2022 Trichosanthes kirilowii, one of the herbal formulas named SH003, has been used for treatment in traditional medicine. This paper aimed to analyze the marker compounds from the roots of T. kirilowii and evaluate a validation method for cucurbitacins B and
Hyoung Ja Kim +3 more
doaj +1 more source
Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice. [PDF]
J Cell Mol Med, 2019 Li J +7 more
europepmc +3 more sources
Cytotoxic Effect of Freeze-Dried Extract of Ecballium elaterium Fruit on Gastric Adenocarcinoma (AGS) and Esophageal Squamous Cell Carcinoma (KYSE30) Cell Lines [PDF]
Purpose Ecballium elaterium (L.) A. Rich (Cucurbitaceae), also known as the “squirting cucumber,” is a wild medicinal plant found abundantly in Moghan, Ardabil province, Iran.
بهلولی, شهاب +2 more
core +1 more source