Results 21 to 30 of about 17,883 (244)

Reactive Oxygen Species-Responsive Nanococktail With Self-Amplificated Drug Release for Efficient Co-Delivery of Paclitaxel/Cucurbitacin B and Synergistic Treatment of Gastric Cancer. [PDF]

Front Chem, 2022
Pang L, Zhang L, Zhou H, Cao L, Shao Y, Li T.   +5 more
europepmc   +2 more sources

Cucurbitacin B from Cucurbitaceae Plants: Treating Pancreatic Cancer via Inducing Mitophagy, Inhibiting Glycolysis, and Enhancing Immune Function. [PDF]

Nutrients
Yin D, Chen H, Jing X, Lin S, Sun Y, Chang R, Feng Y, Dong X, Qu C, Ni J, Yin X.   +10 more
europepmc   +3 more sources

Reduction of Cancer Stem Cells and Invasiveness of Human Melanoma and Breast Cancer by Cucurbitacin B from Lagenaria siceraria

Drugs and Drug Candidates, 2023
Cucurbitacins are secondary metabolites that are commonly found in the Cucurbitacae family. Many biological properties have been reported for cucurbitacins, including anti-inflammatory, antioxidant, antiviral, anti-malaria, and anticancer properties ...
Cheng-Chen Huang, Kiera K. Balding, Sydney J. Zimmerman, Che-Yuan Chang, Si-Min Lu, Hui-Chi Huang   +5 more
doaj   +1 more source

Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities [PDF]

Pharmaceutical Sciences, 2020
For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects,
Moazzameh Ramezani, Melika Hasani, Fatemeh Ramezani, Mahmood Karimi Abdolmaleki   +3 more
openaire   +2 more sources

Cucurbitacins: elucidation of their interactions with the cytoskeleton [PDF]

PeerJ, 2017
Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments.
Xiaojuan Wang, Mine Tanaka, Herbenya Silva Peixoto, Michael Wink   +3 more
doaj   +2 more sources

تشخیص بعض الاحماض الدهنیة ومرکب Cucurbitacin فی مستخلص زیت بعض اجزاء وکالس نبات القرع الجبلی Cucurbita maxima [PDF]

مجلة ابحاث كلية التربية الاساسية, 2021
استخلص زیت نبات القرع الجبلیC.maxima وقدرت نسب وجوده فی الجذور وفی قطع الاوراق والسیقان تحت الفلقیة وفی کالس هذه الاجزاء کنسبة مئویة، وتمکنت الدراسة من تشخیص الاحماض الدهنیة Linolic acid, Oleic acid, Stearic acid, Palmitic acid ، فضلاً عن تشخیص ثلاث ...
islam abdullah
doaj   +1 more source

The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain

Frontiers in Pharmacology, 2023
Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park, Suyong Kim, Ilseob Choi, Ik-Hwan Han, Hyunsu Bae, Woojin Kim, Woojin Kim   +6 more
doaj   +1 more source

Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula)

Frontiers in Plant Science, 2022
Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. However, there is no comprehensive analysis of cucurbitacin biosynthesis in Luffa fruit.
Gangjun Zhao, Meng Wang, Caixia Luo, Junxing Li, Hao Gong, Xiaoming Zheng, Xiaoxi Liu, Jianning Luo, Haibin Wu, Haibin Wu   +9 more
doaj   +1 more source

Cucurbitacin B Inhibits the Proliferation of WPMY-1 Cells and HPRF Cells via the p53/MDM2 Axis. [PDF]

Int J Mol Sci
Jin Y, Zhou P, Huang S, Shao C, Huang D, Su X, Yang R, Jiang J, Wu J.   +8 more
europepmc   +3 more sources

Bioavailability and disposition kinetic of Cucurbitacin B in rats

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018
Natthaphon Hunsakunachai, Weena Jiratchariyakul, Tanawan Kummalue, Phisit Khemawoot   +3 more
openaire   +3 more sources