Results 101 to 110 of about 1,320,602 (281)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Testing the Effect of Cue Consistency on the Past Behavior–Habit–Physical Activity Relationship

Behavioral Sciences
Behavior performed in the presence of consistent cues is a core element for successful habit development, with the repeated presence of consistent cues facilitating the activation of automatic responses in future.
Daniel J. Phipps, Martin S. Hagger, David Mejia, Kyra Hamilton   +3 more
doaj   +1 more source

Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat

Frontiers in Behavioral Neuroscience, 2019
Nicotine is acknowledged as the key addictive compound of tobacco. Varenicline (Champix® or Chantix®), mainly acting as a partial agonist at the α4β2 nicotinic receptor, is an approved smoking cessation pharmacotherapy, although with efficacy limited to ...
Vernon Garcia-Rivas, Vernon Garcia-Rivas, Jean-François Fiancette, Jean-François Fiancette, Nazzareno Cannella, Nazzareno Cannella, Maria Carbo-Gas, Maria Carbo-Gas, Prisca Renault, Prisca Renault, Jessica Tostain, Jessica Tostain, Véronique Deroche-Gamonet, Véronique Deroche-Gamonet   +13 more
doaj   +1 more source

Comprehensive User Engagement Sites (CUES) in Philadelphia: A Constructive Proposal [PDF]

, 2018
This paper is a study about Philadelphia’s comprehensive user engagement sites (CUESs) as the authors address and examine issues related to the upcoming implementation of a CUES while seeking solutions for its disputed questions and plans. Beginning with
Clark, Peter, Cooney, Kevin, DiMeglio, M., Dubensky, J., Gulati, S., Lathrop, S., Lee, Marvin J. H., Minupuri, A., Nguyen, Olivia, Patel, P., Schadt, Sam A., Umapathy, S., Zheng, S.   +12 more
core  

Changing users' security behaviour towards security questions: A game based learning approach

, 2017
Fallback authentication is used to retrieve forgotten passwords. Security questions are one of the main techniques used to conduct fallback authentication. In this paper, we propose a serious game design that uses system-generated security questions with
Arachchilage, Nalin Asanka Gamagedara, Micallef, Nicholas   +1 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A study on the effect of different channel cues on learning in immersive 360° videos

Frontiers in Psychology
Immersive 360° videos are of interest to educators because of their ability to provide immersive sensory experience and other features. This study examined the effects of four cue conditions on 360° video learning performance, attention, cognitive load ...
Guan Huang, Chao Chen, Yahan Tang, Haohua Zhang, Rui Liu, Li Zhou   +5 more
doaj   +1 more source

Know2Look: Commonsense Knowledge for Visual Search

, 2019
With the rise in popularity of social media, images accompanied by contextual text form a huge section of the web. However, search and retrieval of documents are still largely dependent on solely textual cues.
Nag Chowdhury, S., Tandon, N., Weikum, G.   +2 more
core