Results 31 to 40 of about 383,400 (219)

Exploring the Potential of Sunflowers: Agronomy, Applications, and Opportunities within Bio-Circular-Green Economy

open access: yesHorticulturae, 2023
The present review article is intended to provide comprehensive insights into the techniques of sunflower cultivation, methods of processing, and opportunities for value addition through a variety of applications.
Ratchanee Puttha   +7 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Production, marketing, and future prospects of Nepali orthodox tea

open access: yesCogent Food & Agriculture, 2020
Orthodox tea is one of the high-value agriculture commodities having enormous potential of export to international market. Nepal offers suitable climate, soil, and topography for profitable production of the orthodox tea having exceptional flavor, aroma,
Dharmendra Kalauni   +2 more
doaj   +1 more source

Medicinal Mushrooms Ophiocordyceps Sinensis and Paecilomyces Hepiali

open access: yesFolia Veterinaria, 2021
The fungi of the genus Ophiocordyceps sinensis (Berk.) belong to entomopathogenic fungi. Ophiocordyceps sinensis has been used as a tonic and medicinal product in China for more than 2,000 years.
Uhrinová A., Ungvarská Maľučka L.
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Integrating CUREs in Ongoing Research: Undergraduates as Active Participants in the Discovery of Biodegrading Thermophiles

open access: yesJournal of Microbiology & Biology Education, 2021
Research-based courses are a powerful way to engage undergraduates in the scientific process while simultaneously teaching participants relevant laboratory, analysis, and scientific communication skills.
Brent M. Peyton, Dana J. Skorupa
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Evaluation of reproduction for mussel Mytilus trossulus (Bivalvia: Mytilidae) in the Veselaya Bay (Tauiskaya Guba Bay, Okhotsk Sea)

open access: yesИзвестия ТИНРО, 2018
Abundance, size composition, and terms of plankton stage were investigated for the larvae of pacific mussel in the Veselaya Bay (Okhotsk Sea) in two years with different oceanographic regime. The first larvae (density 8-30 ind./m³, shell length 75–150 μm)
V. S. Zharnikov
doaj   +1 more source

Pre-Columbian cultivation of vegetatively propagated and fruit tree tropical crops in the Atacama Desert

open access: yesFrontiers in Ecology and Evolution, 2022
South America is a megadiverse continent that witnessed the domestication, translocation and cultivation of various plant species from seemingly contrasting ecosystems.
José M. Capriles   +6 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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