Results 31 to 40 of about 403,258 (267)

Construction of military disease prevention and control system and thinking on talent cultivation for public health emergency under the pandemic of COVID-19

open access: yesDi-san junyi daxue xuebao, 2020
The pandemic of coronavirus disease 2019 (COVID-19) threatened the people's lives and health all over the world in 2020. China has achieved preliminary success in fighting the epidemic through joint efforts of the whole country.
CAO Jia, LI Ying
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Exploring the Potential of Sunflowers: Agronomy, Applications, and Opportunities within Bio-Circular-Green Economy

open access: yesHorticulturae, 2023
The present review article is intended to provide comprehensive insights into the techniques of sunflower cultivation, methods of processing, and opportunities for value addition through a variety of applications.
Ratchanee Puttha   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Medicinal Mushrooms Ophiocordyceps Sinensis and Paecilomyces Hepiali

open access: yesFolia Veterinaria, 2021
The fungi of the genus Ophiocordyceps sinensis (Berk.) belong to entomopathogenic fungi. Ophiocordyceps sinensis has been used as a tonic and medicinal product in China for more than 2,000 years.
Uhrinová A., Ungvarská Maľučka L.
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Production, marketing, and future prospects of Nepali orthodox tea

open access: yesCogent Food & Agriculture, 2020
Orthodox tea is one of the high-value agriculture commodities having enormous potential of export to international market. Nepal offers suitable climate, soil, and topography for profitable production of the orthodox tea having exceptional flavor, aroma,
Dharmendra Kalauni   +2 more
doaj   +1 more source

Integrating CUREs in Ongoing Research: Undergraduates as Active Participants in the Discovery of Biodegrading Thermophiles

open access: yesJournal of Microbiology & Biology Education, 2021
Research-based courses are a powerful way to engage undergraduates in the scientific process while simultaneously teaching participants relevant laboratory, analysis, and scientific communication skills.
Brent M. Peyton, Dana J. Skorupa
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

Pre-Columbian cultivation of vegetatively propagated and fruit tree tropical crops in the Atacama Desert

open access: yesFrontiers in Ecology and Evolution, 2022
South America is a megadiverse continent that witnessed the domestication, translocation and cultivation of various plant species from seemingly contrasting ecosystems.
José M. Capriles   +6 more
doaj   +1 more source

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