Results 51 to 60 of about 1,425,464 (309)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Development of technology for culturing a cell line producing a single-domain antibody fused with the Fc fragment of human IgG1

Тонкие химические технологии
Objectives. To develop an effective technology for the cultivation of Chinese hamster ovary (CHO) cells stably producing GamP2C5 antibody which is a component I of the GamCoviMab candidate drug for emergency prevention and therapy of  infection caused by
D. S. Polyansky, E. I. Ryabova, A. A. Derkaev, N. S. Starkov, I. S. Kashapova, D. V. Shcheblyakov, A. P. Karpov, I. B. Esmagambetov   +7 more
doaj   +1 more source

Organic rapeseed production in Finland [PDF]

, 2013
Most of the 56 organic rapeseed growers interviewed in this research acknowledged modest success in rapeseed yield (often under 500 kg/ha, on average about 800-900 kg/ha), but kept continuing cultivation because of other benefits such as good price and ...
Hakala, K.
core  

Monitoring of climate variables in semi-closed greenhouses [PDF]

, 2011
Growers and Dutch government have concluded a covenant in which they express the ambition to reduce the carbon footprint of greenhouse production in order to improve the energy neutrality of newly built greenhouses.
Campen, J.B., Dieleman, J.A., Garcia Victoria, N., Gieling, T.H., Janssen, H.J.J., Kempkes, F.L.K., Kromwijk, J.A.M., Raaphorst, M.G.M.   +7 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Microalgae to Biofuel: Cutting‐Edge Harvesting and Extraction Methods for Sustainable Energy Solution

Energy Science & Engineering
The increasing price and demand for fossil fuels are driven by their depletion, greenhouse gas emissions, and industrial air pollution. As a result, the search for renewable alternatives has gained serious attention.
Abu Saleh Ahmed, Alamry Ali, Emre Gorgun, M. Jameel, Tasmina Khandaker, Md. Shaharul Islam, Md. Saiful Islam, Masuk Abdullah   +7 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Development of therapeutic peptide producers based on Escherichia coli BL21 and their cultivation technology

Разработка и регистрация лекарственных средств
Introduction. Peptides with a molecular weight of less than 5 kDa have been used in medicine and biotechnology over the past decade for the treatment of various diseases. However, chemical synthesis peptide has several disadvantages, including low yield,
Z. R. Khasanshina, I. A. Kornakov, E. A. Buslaeva, A. V. Kazakova, S. A. Ishchuk, V. I. Shmurak, V. B. Saparova, V. F. Latypov, R. V. Drai   +8 more
doaj   +1 more source

Portable and Rapid Sequencing Device with Microbial Community-Guided Culture Strategies for Precious Field and Environmental Samples

mSystems, 2021
Culturing unculturable bacteria is a classic microbiology challenge; to successfully culture unculturable bacteria, microbiologists work hard to create hundreds of culture conditions.
Ying-Ning Ho, Yu-Ling Chen, Ding-Yang Liu   +2 more
doaj   +1 more source