Results 41 to 50 of about 386,598 (268)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
DEVELOPMENT OF NUTRIENT MEDIUM AND CULTIVATION REGIMES OF FOR BACTERIAL CONCENTRATE PRODUCTION [PDF]
Техника и технология пищевых производств, 2016 Lactobacillus reuteri has been selected in the All-Russia Dairy Research Institute. The mentioned type of lactic acid bacteria possesses a wide spectrum of functional properties thus the development of L.reuteri bacterial concentrate is actual and ...
Raskoshnaya T.A. +3 more
doaj
Agriculture, 2021 Intermediate wheatgrass (IWG) may benefit soil fertility in crop rotations. To investigate termination strategies, i.e., autumn ploughing (AP), autumn harrowing (AH) and spring harrowing (SH) on a five-year-old IWG stand, a pilot study was performed ...
Linda-Maria Dimitrova Mårtensson +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Penanaman Nilai Karakter Kedisiplinan Melalui Kegiatan Ekstrakurikuler di Sekolah
Jurnal Kewarganegaraan, 2023 Discipline has a significant impact on student character. Discipline is influenced by several factors, one of which is the lack of the role of extracurricular activities in fostering student discipline.
Risa Dwi Angraini +3 more
doaj +1 more source
The Cultivation of Trypanosomata [PDF]
Journal of Hygiene, 1905 Tr. Lewisi has been cultivated by me for nine generations, the duration of cultivation extending over a period of nine months. The culture is still alive and is now in its tenth generation. A culture of Tr. Brucei was cultivated through three generations for a period slightly exceeding eighty days. These cultural experiments, however, in no way compare,
openaire +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Frontiers in Natural ProductsEssential oils (EOs) have a long-standing tradition and remain widely used in therapeutic applications. Their biological activities are primarily driven by complex interactions among their diverse components which exhibit synergistic or antagonistic ...
Usama Ramadan Abdelmohsen +2 more
doaj +1 more source