Results 131 to 140 of about 848,063 (302)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A VIDA COTIDIANA E AS BRINCADEIRAS NO PRIMEIRO ANO DO ENSINO FUNDAMENTAL

Cadernos Cedes
RESUMO: Discute-se se e de que forma a atividade lúdica tem integrado o currículo de primeiros anos do ensino fundamental. Para tal, apresentam-se resultados de pesquisa bibliográfica, realizada na Biblioteca Digital Brasileira de Teses e Dissertações ...
Maria Silvia Pinto de Moura Librandi da Rocha, Rosângela Benedita Ribeiro   +1 more
doaj   +1 more source

Valuing Historic Places: Traditional and Contemporary Approaches [PDF]

, 2010
Decisions about which older buildings, structures, and places should be conserved are fundamental to the practice of architectural conservation. Conservation professionals use the interrelated concepts of integrity, authenticity, and historical value to ...
Wells, Jeremy C.
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

The establishment of the Institute of Chartered Accountants of India (ICAI): the first step in the development of an accounting profession in post-independence India [PDF]

, 2006
This paper analyses the influence of culture and politics on the establishment of the Institute of Chartered Accountants of India (ICAI) using a theoretical framework, extending the work of Gray (1988) and McKinnon (1986) in which accounting change is ...
Gray, S.J., Verma, S.
core  

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source

Cultural-historical reflection on learning, place, and legacy of Vygotsky

Культурно-историческая психология
Context and relevance. This reflective paper explores the significance of personal academic experience in advancing understanding of Cultural-Historical Theory (CHT) and Activity Theory (AT). Objective.
E. Rzyankina, J.S. Vitko, D. Novaes Gomes Pereira, D. Ribeiro Gomes, G.D. Emelin, N.L. Savchenko, M. Dalla Vecchia, M. Alonso, L.M. Furtuoso, H.M. Almeida, S. Kumar   +10 more
doaj   +1 more source

Studying and Supporting Writing in Student Organizations as a High-Impact Practice [PDF]

, 2016
Institutions of postsecondary education, and the field of writing across the curriculum and in the disciplines (WAC/WID) in particular, need to do more to trouble learning paradigms that employ writing only in service to particular disciplines, only in ...
Hendrickson, Brian
core   +1 more source