Results 91 to 100 of about 1,321,495 (304)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The foundations of an inclusive paradigm for contemporary education
Specialusis Ugdymas, 2018 The aim of the article is a theoretical modeling of the inclusive paradigm of contemporary education. The study was based on a literature study and secondary data analysis. The article presents the data collected in Russia in 2014-2017.
Svetlana V. Alekhina +2 more
doaj +1 more source
Rethinking professional learning in higher education: a study on how the use of Open Educational Resources triggers the adoption of Open Educational Practice [PDF]
, 2017 This study explores how the practices of higher education educators evolve towards open educational practice (OEP) as they use open educational resources (OER) as a form of social media.
Hood, Nina +2 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Warburg und die Natur(-wissenschaft): Affektpsychologische Fundierung von Kultur im Hamburger Kreis um Warburg, Cassirer und Werner und deren Nachwirkungen [PDF]
, 2020 What distinguishes humans form animals? Acknowledging that humans are part of nature, that can process psychologically their affective-vital reactions to nature, and thus be held responsible for cultural processes, is the result of art historical ...
Sauer, Martina
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FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
CULTURE UNDER A HISTORICAL-CULTURAL PERSPECTIVE: FIRST APPROACHES
Travessias, 2008 This paper derives from a study developed in a Masters Degree lato sensu course focusing the Historical-Cultural Theory, which was offered by the State University of Maring-UEM. It is an investigation, in first approach, regarding the meaning of culture,
Renata Almeida Vieira
doaj
Bellaterra Journal of Teaching & Learning Language & Literature, 2011 Review of the book entitled Cultural-Historical Perspectives on Teacher Education and Development: Learning Teaching, 2010, Routledge: Taylor & Francis Group, London and New York (Edited by Viv Ellis, Anne Edwards, and Peter Smagorinsky).
Victoria Antoniadou
doaj +1 more source
Organic Selection and Social Heredity: The Original Baldwin Effect Revisited [PDF]
, 2019 The so-called “Baldwin Effect” has been studied for years in the fields of Artificial Life, Cognitive Science, and Evolutionary Theory across disciplines.
Le, Nam
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