Results 141 to 150 of about 571,184 (317)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Native Peoples-Native Homelands Climate Change Workshop Final Report: Circles of Wisdom [PDF]
, 1998 The Native Peoples-Native Homelands Climate Change Workshop was held on October 28 through November 01, 1998, as part of a series of workshops being held around the U.S.
U.S. Global Change Research Program +1 more
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Raw material choices and technical practices as indices of cultural change: Characterizing obsidian consumption at 'Mycenaean' Quartier Nu, Malia (Crete). [PDF]
PLoS One, 2022 Carter T, Kilikoglou V.
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Involvement and skepticism towards the JCI Accreditation process among hospital's four sectors employees: suggestions for cultural change. [PDF]
Isr J Health Policy Res, 2021 Bord S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Cultural change beyond adoption dynamics: Evolutionary approaches to the discontinuation of contraception. [PDF]
Evol Hum Sci, 2021 Alvergne A, Stevens R.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A Model-Based Method for Detecting Persistent Cultural Change Using Panel Data. [PDF]
Sociol Sci, 2021 Vaisey S, Kiley K.
europepmc +1 more source
Conceptualizing Cultures of Violence and Cultural Change [PDF]
, 2007 The historiography of violence has undergone a distinct cultural turn as attention has shifted from examining violence as a clearly defined (and countable) social problem to analysing its historically defined 'social meaning'. Nevertheless, the precise nature of the relationship between 'violence' and 'culture' is still being established.
openaire +2 more sources