Results 151 to 160 of about 3,425,802 (309)
Parents, television and cultural change [PDF]
, 2011 This paper develops a model of cultural transmission where television plays a central role for socialization. Parents split their free time between educating their children which is costly and watching TV which though entertaining might socialize the ...
Hauk, Esther +3 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Journal of Educational, Cultural and Psychological Studies, 2010 History of the Cinema and History in the Cinema. Reflecting with Gianfranco Gori and Pierre Sorlin on Questions of Methods and Didactic Proposals This essay offers reflections on methodological issues and proposals of didactic paths through the author’s
Carlo Felice Casula
doaj
Destroying the Ethnosphere? How Tourism Has Impacted the Sherpas of Nepal
, 2014 Tourism is perhaps the most salient and impactful process of globalization today. As we are increasingly more mobile, traveling with endless comfort and ease, we explore the far reaches of the planet as ambassadors of our own culture and as agents of ...
Ginder, Joshua H.
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Northern Vanuatu as a Pacific Crossroads: The Archaeology of Discovery, Interaction, and the Emergence of the "Ethnographic Present" [PDF]
, 2015 Northern Vanuatu is a significant crossroads region of the Southwest Pacific. This paper outlines current archaeological research being undertaken in the area, focusing on defining initial human settlement there some 3000 years ago and subsequent ...
Bedford, Stuart, Spriggs, Matthew
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Sustain Arts/SE Michigan: A Portrait of the Cultural Ecosystem [PDF]
, 2014 This report discusses the potential use of data in arts organizations for strategic purposes. Data currently available on the cultural sector can lead to useful insights about the increasing proliferation of small arts organizations; the almost ...
Kiley Arroyo +2 more
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source