Results 81 to 90 of about 3,418,859 (310)

Organisational culture and information systems implementation: a critical perspective [PDF]

open access: yes, 2003
This research explores how information systems (IS) implementation is accomplished when cultural change of an organisation is attempted and what this accomplishment means for those touched by it.
McGrath, Kathy
core  

Cultural Responses to Climate Change During the Late Holocene [PDF]

open access: yes
This study describes the effect of drought on past civilizations and peoples and their response as civilizations or cultures. The site includes four case studies drawn from New and Old World civilizations that document societal responses to prolonged ...
Peter deMenocal
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Problemy marginalizowane i zapoznane w dyskursie o tożsamości pedagogiki

open access: yesPaedagogia Christiana, 2014
W dyskursie nad tożsamością pedagogiki wyodrębnić możemy problemy stale w nim obecne, ale także problemy marginalizowane i zapoznane (zapomniane) w określonym miejscu i czasie historycznym. Świadomość procesu zapominania i odzyskiwania problemów i wiedzy
Teresa Hejnicka-Bezwińska
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

María Elena: el fin de una experiencia urbana: Un estudio de caso en el desierto de Atacama, Chile

open access: yesEURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales, 2009
En el presente trabajo se plantea la relación entre la ciudad salitrera de María Elena (II Región), diseñada de acuerdo a propuestas utópicas en un territorio privado, y el cambio de las relaciones laborales entre la Compañía SQM y los trabajadores a ...
JUAN CARLOS RODRÍGUEZ TORRENT   +1 more
doaj  

INSTITUTIONAL Change as Cultural Change. An Illustration by Chinese Postsocialist Transformation [PDF]

open access: yes
Culture of a society reflects its social values. So, through Chinese experience, we want to show that institutional change is not only an economic or a political process but fundamentally a cultural one.
EL KAROUNI, Ilyess
core   +1 more source

Thinking Materially: Cognition as Extended and Enacted [PDF]

open access: yes, 2017
Human cognition is extended and enacted. Drawing the boundaries of cognition to include the resources and attributes of the body and materiality allows an examination of how these components interact with the brain as a system, especially over cultural ...
Overmann, Karenleigh A.
core  

Governance and the transformation of political representation [PDF]

open access: yes, 2005
About the book: There has been an explosion of new forms of governance as societies adapt to economic, social and political change. This book highlights the dynamics of the social, cultural and institutional practices involved in 'remaking' governance ...
Saward, Michael
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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