Results 71 to 80 of about 3,418,859 (310)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Cultural Change

open access: yes, 2023
AbstractDespite culture’s tendency to stability, change does occur. This chapter draws from research-based examples of cultural change to reveal triggers and processes of cultural change. It explores how change can be initiated through adjustments in external influences, and/or internal (actor-driven) adjustments of a feature of their cultural ensemble.
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Archeological and mtDNA evidence for Tropical Lowland migrations during the Late Archaic / Formative in northern Chile Evidencia arqueológica y de ADNmt para migraciones de Tierras Bajas Tropicales Durante el Arcaico Tardío/Formativo Temprano en el norte de Chile

open access: yesRevista Chilena de Historia Natural, 2009
The influence of tropical lowland migrations on the emergence of cultural change in the Central Andes has been postulated in general terms since the beginning of last century (Tello 1929).
FRANCISCO ROTHHAMMER   +5 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Ten Years toward Equity: Preliminary Results from a Follow-Up Case Study of Academic Computing Culture

open access: yesFrontiers in Psychology, 2017
Just over 10 years ago, we conducted a culture study of the Computer Science Department at the flagship University of Illinois at Urbana-Champaign, one of the top five computing departments in the country. The study found that while the department placed
Tanya L. Crenshaw   +3 more
doaj   +1 more source

Alcohol and other drugs in the Australian construction industry: a pathway for safety focused cultural change [PDF]

open access: yes, 2013
Background: Anecdotal evidence from the infrastructure and building sectors highlights issues of alcohol and other drugs (AODs) and its association with safety risk on construction sites.
Biggs, Herbert, Williamson, Amy
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Education as a factor of cultural reproduction and cultural production [PDF]

open access: yesBaština, 2020
Striving to emphasize the complex and dynamic relationships and mutual connection between the concepts of education and cultures, the aim of this work is to present the role of education in the process of cultural reproduction and the process of cultural
Nikolić Nataša T.   +1 more
doaj  

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