Results 91 to 100 of about 6,240,707 (340)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

UNIVERSITY EDUCATION OF SPECIALISTS IN INTERNATIONAL AFFAIRS AS A WAY OF PASSING CULTURAL CODE

Vestnik MGIMO-Universiteta, 2014
The article describes the cultural code approach to the process of higher education requires global understanding and awareness of the integrity of academic studies at the university, comprising both professional and humanitarian disciplines, such as ...
I. M. Shepeleva
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Testing Hypothesis about the Prototext through Content Analysis in Cinematography: The Case of “Pretty Woman”

Галактика медиа: журнал медиа исследований
For decades, Harry Marshall’s romantic comedy “Pretty Woman” has been attracting public and critics’ the attention. The authors of the article suggest that the reason lies in the existence of a hidden meaning that contrasts with the overt celebration of ...
Nikolay S. Babich, Anastasia A. Vlasova-Yagodina   +1 more
doaj   +1 more source

Ideological inequalities: Khmer culture and widows' perception of remarriage [PDF]

, 2018
To explain the enduring persistence of gender inequality, structural explanations alone are not sufficient. One must look at the realm of cultural ideas to understand the entrenched nature of female subordination.
Lee, Susan
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Folk Play in Presenting Traditions and Representing Cultural Code. Traditional [PDF]

, 2016
Традиційні види спорту та ігри – наразі досить затребуваний на- прям у вітчизняних і зарубіжних наукових розвідках; у ЮНЕСКО їх проголошено частиною нема- теріальної спадщини й симво- лом культурного розмаїття на- шого суспільства. Цінність до- слідження
Sainchuk, Mykola, Саїнчук, Микола   +1 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Provincial Text of Russian Literature: Steel City and a Person (on Works of Lipetsk Writers)

Научный диалог, 2018
The problem of the modern provincial local text on the example of the works of Lipetsk authors is considered. The phenomenon of the Lipetsk text consists in the fact that it has both a long tradition (A. A. Shakhovsky, the author of the comedy “Lesson to
V. S. Rastorguyeva
doaj   +1 more source