Results 91 to 100 of about 149,666 (298)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
National cultural code in the Ukrainian blogosphere: Instagram, TikTok, Facebook
, 2023 Дисертаційне дослідження присвячене проблемі функціонування національного культурного коду в українській блогосфері, а саме: в інстаграмі, тіктоці, фейсбуці, актуальність якої зростає у зв’язку з впливом соціальних мереж на формування громадської думки ...
Сергєєва Анна Олександрівна
core
SOCIAL NETWORKS OF THE INTERNET WITHIN THE THEORY OF AUTOPOIESIS BY NIKLAS LUHMANN
Вестник университета, 2016 The social networks existing for centuries as social communities in family and companionship, achieved new opportunities of self-updating and public expression with the emergence of the Internet and formation social networks in it.
E. Yudina, S. Zakharova
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Cultural Code in Scientific and Journalistic Dimensions
This article explores the distinctive features of the term “cultural code” within scientific and journalistic discourses. The materials for analysis are drawn from newspaper articles and partially from the main corpus of the Russian National Corpus, as ...
O. A. Dimitrieva
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2009 Includes bibliographical references (82-86).In this study, I examine language contact phenomena exhibited by two groups of young middle-class Syrian citizens. Members of one group were born and have been living with their families in Riyadh, Saudi Arabia.
Mozaic, Zeina
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source