Results 41 to 50 of about 149,666 (298)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2021 Code for: Lorenz, T., & Algner, M. (2021). Lost in translation or just too pragmatic? Validation of the German Broader Autism Phenotype Questionnaire (BAPQ-G).Psychological Test Adaptation and Development. Advance online publication.
Lorenz, Timo, Algner, Mona
core +1 more source
Reconstruction of vanished cities
Проект БайкалThe preservation of historical heritage has the potential to act as a means of regenerative design in line with the concept of sustainable architecture.
Nasirdinova Насирдинова +2 more
doaj +1 more source
КЛУБ МЕЖКУЛЬТУРНОЙ КОММУНИКАЦИИ КАК СРЕДСТВО РЕАЛИЗАЦИИ ТРЕТЬЕЙ МИССИИ УНИВЕРСИТЕТА
Научно-педагогическое обозрение, 2022 Ставится проблема необходимости интенсифицировать каналы и формы взаимодействия с иностранными студентами в российских университетах, которые сегодня призваны не только проводить научные исследования и обучать, но также влиять на совершенствование ...
Чернышева Татьяна Леонидовна
doaj +1 more source
Визуальная теология, 2022 Historical research on medieval universities is not fully capable of revealing the specifics of this unique phenomenon. The multidimensionality of reality, as well as human reactions to it, cannot be exhausted by knowledge and explanation of the material
Nikolai Tokarev / Николай Васильевич Токарев
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Construction & deconstruction of linguistic otherness: conflict & cooperative code-switching in (English/) bilingual classrooms [PDF]
, 2009 The socio-cultural settings of English-language and Englishmedium classrooms are intrinsically bi/multilingual and bi/multicultural as both learners and teachers bring their multiple identities and home-community languages and sociolinguistic practices ...
Saxena, Mukul
core
, 2003 In the enormous collection of cross-cultural data that have been published during the last few decades it is difficult to perceive patterns. There is a clear need for systematizing the vast amount of cross-cultural studies and for developing models that ...
Dianne A. van Hemert +2 more
core +1 more source