Results 51 to 60 of about 868,553 (328)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Towards an Enterprises’ Cross-Cultural Competence Scale

SAGE Open
Enterprises engaged in international business have been playing a crucial role in international business arena and their cross-cultural competence, as a type of dynamic capability, is indispensible.
Jing Jiao, Jiayi Jin, Xiaoyu Feng, Xiuqing Zhao   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A virtual training program for improving cultural competence among academic nurse educators

BMC Medical Education, 2023
Background Everyday, nursing students interact with culturally diverse clients. Nursing education recognizes that cultural competence is a necessary outcome of nursing programs.
Monireh Rahimi, Sedigheh Khodabandeh Shahraki, Farhad Fatehi, Jamileh Farokhzadian   +3 more
doaj   +1 more source

One Size Does Not Fit All: Meeting the Health Care Needs of Diverse Populations [PDF]

, 2008
Proposes a framework for meeting patients' cultural and linguistic needs: policies and procedures that support cultural competence, data collection, population-tailored services, and internal and external collaborations.
Amy Wilson-Stronks, April L. Kopp, Christina L. Cordero, Erica Galvez, Karen K. Lee   +4 more
core  

The CARESSES study protocol: testing and evaluating culturally competent socially assistive robots among older adults residing in long term care homes through a controlled experimental trial [PDF]

, 2020
Background : This article describes the design of an intervention study that focuses on whether and to what degree culturally competent social robots can improve health and well-being related outcomes among older adults residing long-term care homes. The
Battistuzzi, Linda, Castro, Nina, Chong, Nak-Young, Davidson, Rosemary, Hewson, David, Hill, Tetiana, Kamide, Hiroko, Kanoria, Sanjeev, Merton, Len, Nigath, Abiha, Papadopoulos, Chris, Randhawa, Gurch, Sgorbissa, Antonio   +12 more
core   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Knowledge, skill, and awareness of physiotherapists on cultural competence in southwest Nigeria

Bulletin of Faculty of Physical Therapy
Background Physiotherapists need to be culturally competent to provide effective services to healthcare users of diverse cultures. Here, we investigated the association between selected sociodemographic characteristics and the knowledge, skills, and ...
Joana Adeleke, Victor Adelua, Joseph Ayotunde Aderonmu, Michael Opeoluwa Ogunlana   +3 more
doaj   +1 more source

Assessing Culture Competence Among Nurses in an Acute Care Setting [PDF]

, 2009
The aim of the study was to assess cultural competence among nurses in an acute care setting. A 25-item questionnaire developed by Campinha-Bacote (2003) titled Inventory to Assess Cultural Competence Among Health Care Providers (IAPCC-R) along with a ...
Virani, Maleka
core   +1 more source