Results 151 to 160 of about 6,392,593 (355)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The emergence of polarised groups through source filtering

Humanities & Social Sciences Communications
Polarisation is a widespread societal issue, dividing populations into opposing groups whose beliefs may span multiple, seemingly unrelated, topics. This phenomenon creates distinct cultural groups with internally consistent yet mutually opposing beliefs,
Fredrik Jansson, Anandi Hattiangadi
doaj   +1 more source

The Evolution of Digital Cultural Heritage Research: Identifying Key Trends, Hotspots, and Challenges through Bibliometric Analysis

Sustainability
Heritage preservation fundamentally represents an act of communication, with digitization and virtual access driving cultural heritage research development and dissemination.
Yuntao Lian, Jiafeng Xie
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Cultural Discourse of the Cinematic Language Evolution

, 2021
E. Horyslavets
openalex   +2 more sources

The cultural evolution of age-at-marriage norms [PDF]

We present an agent-based model designed to study the cultural evolution of age-at-marriage norms. We review theoretical arguments and empirical evidence on the existence of norms proscribing marriage outside of an acceptable age interval.
Alexia Prskawetz, Francesco C. Billari, Johannes Fürnkranz   +2 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Grouping sounds into evolving units for the purpose of historical language comparison [version 2; peer review: 2 approved]

Open Research Europe
Computer-assisted approaches to historical language comparison have made great progress during the past two decades. Scholars can now routinely use computational tools to annotate cognate sets, align words, and search for regularly recurring sound ...
Cristian Juárez, Frederic Blum, Johann-Mattis List, Nathan W. Hill   +3 more
doaj   +1 more source

Cultural additivity – means of human survival and evolution

, 2022
Quy Van Khuc
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source