Results 101 to 110 of about 605,885 (292)

Cantieri aperti per progetti di fruizione del Cultural Heritage digitalizzato

Storicamente, 2013
The transition from Web 1.0 to Web 2.0 and the subsequent dissemination of technologies and products of the approach of open Information and Communication Technologies (ICT) make stronger the link between technology and Cultural Heritage (CH), giving new
Elisa Bassani, Elena Rosa, Matteo Sgherri   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Observing Users - Designing clarity a case study on the user-centred design of a cross-language information retrieval system [PDF]

, 2004
This paper presents a case study of the development of an interface to a novel and complex form of document retrieval: searching for texts written in foreign languages based on native language queries.
Ballesteros, Bathie, Beaulieu, Beaulieu, Belkin, Borlund, Brajnic, Capstick, Capstick, Carroll, Chen, Cousin, Dumais, Dumais, Gachot, Golovchinsky, Gonzalo, Hackos, He, Hearst, Hendry, Hull, Koenemann, Leuski, McCarley, Nielsen, Norman, Oard, Oard, Ogden, Petrelli, Petrelli, Pirkola, Preece, Preece, Radwan, Rosson, Salton, Sanderson, Schuler, Xu   +40 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Relevance of Evolutionary Science For Economic Theory and Policy [PDF]

NSF’s “Dear Colleague Letter” reflects the widely perceived need to go beyond current economic theory in the formulation of public policy. At the same time, there is a profound lack of unity among the disciplines that comprise the behavioral, social, and
David Sloan Wilson, John M. Gowdy
core  

Ethnobotanical survey of pesticidal plants used in South Uganda : case study of Masaka district [PDF]

, 2011
Use of synthetic pesticides in developing countries is not only limited by their being expensive but also the small (uneconomic) fields whose limited production costs cannot offset costs of agricultural implements like agro-chemicals. Subsistence farmers,
Charles, Kudamba, Gerard, Kamoga, Mwine, Tedson Julius, Van Damme, Patrick   +3 more
core  

The Formulation of the Cultural Identity of Interior Architecture Students through the Educational Globalization

ARCHive-SR, 2017
Educational Globalization debilitates the identities, the origins and cultural, religious, etymological, racial, and ethnic foundations— challenge a country's feeling of solidarity and cohesion.
Noha Khamis, Hassan Abdel Moniem Metwalli   +1 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Diffusion of Humans and Cultures in the Course of the Spread of Farming

, 2017
The most profound change in the relationship between humans and their environment was the introduction of agriculture and pastoralism. [....] For an understanding of the expansion process, it appears appropriate to apply a diffusive model. Broadly, these
B Arıkan, BG Purzycki, C Jeunesse, C Lemmen, C Lemmen, C Lemmen, C Lemmen, D Gronenborn, D Gronenborn, F Silva, F-X Ricaut, G Barker, G Brandt, J Fort, J-P Bocquet-Appel, J-P Bocquet-Appel, JGD Clark, K Davison, K Manning, KW Wirtz, KW Wirtz, M Rivollat, M-J Gaillard, RA Fisher, SJ Shennan, W Haak, W Schier, WF Ruddiman   +27 more
core   +1 more source