Results 81 to 90 of about 605,885 (292)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Possibilities of culture tourism advancement in Požarevac: Formulation and realisation of cultural tour [PDF]

Turističko Poslovanje, 2019
Culture tourism represents a significant part of the tourist market, and as such, it includes a wide spectrum of cultural and historic values, that possess efficient tourism properties for tourist traffic and tourism income.
Antić Aleksandar
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Does related variety matter for creative employment growth? [PDF]

, 2015
Little progress has been made in the mitigation of the controversies surrounding creativity and its role for local economic development (FLORIDA, 2002; PECK, 2005).
SIMONE, ANDREA
core  

Philosophical Introspection on Educational and Cultural Inheritance in Strategy Formulation of Overseas Chinese Schools in the Post-Pandemic Era

Trans/Form/Ação
It is upheld that overseas Chinese language schools (CLSs) are crucial in providing Chinese heritage language education to overseas Chinese children. In this study, we used case studies to examine the strategy development of CLSs from the perspective of
Zhiling Yang
doaj   +1 more source

KEBIJAKAN FORMULASI TINDAK PIDANA PENCEMARAN NAMA BAIK DALAM BIDANG TEKNOLOGI INFORMASI

Jurnal Cakrawala Hukum, 2017
The current legal regulation related to the formulation of criminal defamation in information technology is the problem of legal obscurity that causes juridical problem in its implementation.
Galih Puji Mulyono
doaj   +1 more source

Working with the cultural formulation in therapy

European Psychiatry, 2008
AbstractThe Cultural Formulation of Diagnosis, put away in the Appendix IX in the DSM-IV, was developed during the preparation of the DSMIV by the NIMH group Culture and Diagnosis, a group of international cultural experts to make the manual more culturally sensitive.
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Impregnant formulation to the preservation, protection and consolidation of wood heritage assets [PDF]

, 2018
The protection of cultural heritage is an integral part of the world´s material wealth. The cultural heritage, movable and immovable, together with the natural environment, represents values that contribute to the education and social culture of the ...
Alfieri, Paula Vanesa, Canosa, Guadalupe, Lofeudo, Rosana   +2 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source