Results 71 to 80 of about 605,885 (292)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Cultural Environment Approach of Urban Development: the Case Study of the City of Veria, Greece. [PDF]

open access: yes
The culture of any city undoubtedly promotes its development. The formulation and implementation of cultural policies, a key issue for urban economic development, relate to a variety of economic sectors.
Alex Deffner   +2 more
core  

Construction of early childhood and ECCD service provisioning in India [PDF]

open access: yes, 2011
There has been a growing recognition among scholars in childhood studies that childhood is a social construction. Several historical and cross-cultural studies conducted across the world validate this argument, and whereby explains the variability that ...
Aruldoss, Vinnarasan
core  

Challenges of Organised Community Resistance in the Context of Illicit Economies and Drug War Policies: Insights from Colombia

open access: yesJournal of Illicit Economies and Development, 2019
The voice and role of communities, particularly their capacity to organise and resist, has been understudied in the specialised literature on illicit crops and largely ignored in policy debates.
María Alejandra Vélez, Iván Lobo
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Research on the Coordination between Cultural Heritage Protection and Sustainable Tourism Development [PDF]

open access: yesSHS Web of Conferences
This paper studies the coordinated relationship between cultural heritage protection and sustainable tourism development. Firstly, it introduces the concept and value of cultural heritage, including its definition, classification, historical and social ...
Yang Shuhan
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Indicators and Components of Green Human Resource Management with a Social Responsibility Approach in Organizations [PDF]

open access: yesIranian Evolutionary Educational Psychology Journal, 2023
Green human resource management is, in fact, the most fundamental element of organizational sustainability and a foundation for the development of social responsibilities within any organization. The Education Organization plays a significant role in the
Maliheh Tabbodi   +2 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

DE SOFTWARE PARA AUDIOVISUAL: as infl uências da Abragames na formulação de políticas públicas culturais para jogos digitais no Brasil

open access: yesRevista de Políticas Públicas, 2018
Observing the actions of sectoral associations in the process of formulating public policies allows to understand the interests involved by the representati- ves of a cultural productive sector through the scheduling of their actions and discourses in ...
Pedro Santoro Zambon   +1 more
doaj  

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